Results 41 to 50 of about 306,696 (351)
Molecular Oncology, EarlyView.This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang +10 more
wiley +1 more source
Digital Chinese Medicine, 2023 Objective: To explore the therapeutic effects of ginseng total saponins (GTSs) on cognitive impairments in astronauts caused by prolonged exposure to microgravity environment.
Dong Lijinchuan +8 more
doaj
Adaptability of Japanese Quail Chicks to Conditions of Simulated Weightlessness [PDF]
Acta Veterinaria Brno, 2003 The objective of this study was to evaluate the adaptability of young Japanese quail chicks to the simulated weightlessness, represented by hypodynamy. Unsexed hatchlings were subjected to hypodynamy on either the first, second or third day of age and reared under these conditions to 21 days of age.
P. Škrobánek, M Hrancova
openaire +3 more sources
Molecular Oncology, EarlyView.Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan +10 more
wiley +1 more source
Shiyan dongwu yu bijiao yixueObjective To establish a weightlessness simulation animal model using miniature pigs, leveraging the characteristic of multiple systems’ tissue structures and functions similar to those of humans, and to observe pathophysiological changes, providing a ...
TU Yingxin +11 more
doaj +1 more source
Billiard dynamics of bouncing dumbbell [PDF]
, 2013 A system of two masses connected with a weightless rod (called dumbbell in this paper) interacting with a flat boundary is considered. The sharp bound on the number of collisions with the boundary is found using billiard techniques. In case, the ratio of masses is large and the dumbbell rotates fast, an adiabatic invariant is obtained.
arxiv +1 more source
arXiv, 2022 We show that the perverse t-structure induces a t-structure on the category $\mathcal{D}^A(S,\mathbb{Z}_\ell)$ of Artin $\ell$-adic complexes when $S$ is an excellent scheme of dimension less than $2$ and provide a counter-example in dimension $3$. The heart $\mathrm{Perv}^A(S,\mathbb{Z}_\ell)$ of this t-structure can be described explicitly in terms ...
arxiv
On the shape of a lightweight drop on a horizontal plane [PDF]
Phys. Scr. 85 (2012) 045401, 2013 The shape of drop on a flat horizontal plane is obtained by including the first order of correction by the weight. The sphere solution of the weightless drop is used to introduce a new polar coordinate by which the perturbative expression for a region of a drop can be extended analytically to the entire surface of a drop having both the concave and the
arxiv +1 more source
Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations
FEBS Open Bio, EarlyView.We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei +7 more
wiley +1 more source