The Physiological Consequences of Bed Rest
, 2007 Bed rest often is used to treat a wide variety of medical conditions. However, bed rest results in profound deconditioning of the body. Bed rest reduces the hydrostatic pressure gradient within the cardiovascular system, reduces muscle force production,
Drury, Daniel G., Stuempfle, Kristin J.
core
Frontiers in PhysiologyBackgroundAlterations in the circulating concentrations and target-tissue action of organokines underpin the development of insulin resistance in microgravity and gravity deprivation.
Kiera Ward +5 more
doaj +1 more source
Prevention of bone mineral changes induced by bed rest: Modification by static compression simulating weight bearing, combined supplementation of oral calcium and phosphate, calcitonin injections, oscillating compression, the oral diophosphonatedisodium etidronate, and lower body negative pressure [PDF]
The phenomenon of calcium loss during bed rest was found to be analogous to the loss of bone material which occurs in the hypogravic environment of space flight. Ways of preventing this occurrence are investigated.
Donaldson, C. L. +9 more
core +1 more source
NeuroImage, 2020 Episodic memory depends decisively on the hippocampus and the parahippocampal gyrus, brain structures that are also prone to exercise-induced neuroplasticity and cognitive improvement. We conducted a randomized controlled trial to investigate the effects
Anika Friedl-Werner +4 more
doaj +1 more source
Pharmacologic counter measures minimizing post-space flight orthostatic intolerance [PDF]
The effect of bed rest on drug disposition and physiological function was investigated as part of a project to determine the cardiovascular effects of space flight. One group of subjects was given doses of lidocane, penicillin-G, and ICG during a control
Harrison, D. C., Kates, R.
core +1 more source
Frontiers in Physiology, 2018 Hypoxia and confinement have both been shown to influence emotional state. It is envisaged that the inhabitants of future planetary habitats will be exposed to concomitant confinement, reduced gravity and hypoxia. We examined the independent and combined
Nektarios A. M. Stavrou +6 more
doaj +1 more source
Effect of long-term hypokinesia on the electrolytic composition of the blood in patients with osteoarticular tuberculosis [PDF]
Seventy-six patients with osteoarticular tuberculosis were divided into two groups, one of which was required to maintain strict bed rest and the other of which was allowed unrestricted motor activity.
Zakutaeva, V. P.
core +1 more source
Effect of aerobic capacity on Lower Body Negative Pressure (LBNP) tolerance in females [PDF]
This investigation determined whether a relationship exists in females between: (1) aerobic capacity and Lower Body Negative Pressure (LBNP); and (2) aerobic capacity and change in LBNP tolerance induced by bed rest. Nine females, age 27-47 (34.6 plus or
Fortney, Suzanne M. +2 more
core +1 more source
Space-flight simulations of calcium metabolism using a mathematical model of calcium regulation [PDF]
The results of a series of simulation studies of calcium matabolic changes which have been recorded during human exposure to bed rest and space flight are presented.
Brand, S. N.
core +1 more source
Bed Rest and Hypoxic Exposure Affect Sleep Architecture and Breathing Stability
Frontiers in Physiology, 2017 Objective: Despite over 50 years of research on the physiological effects of sustained bed rest, data characterizing its effects on sleep macrostructure and breathing stability in humans are scarce.
Shawnda A. Morrison +8 more
doaj +1 more source