Results 71 to 80 of about 306,696 (351)
Computer simulation of preflight blood volume reduction as a countermeasure to fluid shifts in space flight [PDF]
Fluid shifts in weightlessness may cause a central volume expansion, activating reflexes to reduce the blood volume. Computer simulation was used to test the hypothesis that preadaptation of the blood volume prior to exposure to weightlessness could ...
Charles, J. B. +2 more
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Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics
Advanced Biology, EarlyView.This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim +3 more
wiley +1 more source
Ground experiments for finding principles and working out methods for preventing adverse effects of weightlessness on the human organism [PDF]
A comparative assessment of the effectiveness of different prophylactic procedures to prevent the adverse effects of weightlessness is presented. It is concluded that: physical training is most effective but no single method by itself produces the full ...
Gregoryev, A. I. +3 more
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Advanced Biology, EarlyView.Coacervation driven by liquid‐liquid phase separation (LLPS) of biopolymers has garnered increasing attention in biology since this leads to the formation of membraneless organelles capable of performing essential yet largely unknown functions. This review highlights recent advances in coacervates (artificial condensates) composed of low‐molecular ...
Sayuri L. Higashi, Masato Ikeda
wiley +1 more source
Laboratory simulation of the action of weightlessness on the human organism [PDF]
A brief history of attemps by the U.S. and the U.S.S.R. to simulate weightlessness in the laboratory is presented. Model for laboratory modeling of weightlessness included the bed regimen, the clinostat, and water immersion.
Genin, A. M.
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Advanced Biology, EarlyView.Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang +6 more
wiley +1 more source
A Systems Approach to the Physiology of Weightlessness [PDF]
A systems approach to the unraveling of the complex response pattern of the human subjected to weightlessness is presented. The major goal of this research is to obtain an understanding of the role that each of the major components of the human system ...
Leach, Carolyn S. +3 more
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Toward Design Principles for Biomolecular Condensates for Metabolic Pathways
Advanced Biology, EarlyView.Biomolecular condensates are membrane‐less compartments found through‐out nature which can serve as reaction crucibles for biochemical processes. This review explores the design strategies underlying how condensates can be used in biotechnology to enhance multistep enzyme cascades including enhancement by mass action and substrate channeling, and ...
Alain A.M. André +3 more
wiley +1 more source
A note on $p$-adic simplicial volumes [PDF]
arXiv, 2020 We define and study generalizations of simplicial volume over arbitrary seminormed rings with a focus on $p$-adic simplicial volumes. We investigate the dependence on the prime and establish homology bounds in terms of $p$-adic simplicial volumes. As the main examples we compute the weightless and $p$-adic simplicial volumes of surfaces.
arxiv
Aerospace Medicine and Biology: A continuing bibliography with indexes (supplement 290) [PDF]
This bibliography lists 125 reports, articles and other documents introduced into the NASA scientific and technical information system in October ...
core +1 more source