Results 81 to 90 of about 1,127,856 (277)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

On a Class of human development index measures [PDF]

open access: yes
Using Minkowski distance function we propose a class of Human Development Index measures. Special cases of this turn out to be the popularly used linear average method as also a newly proposed displaced ideal method. Two measures of penalty are suggested.
Hippu Salk Kristle Nathan, Srijit Mishra
core   +3 more sources

Illness and determinants of health-related quality of life in a cross-sectional sample of schoolchildren in different weight categories

open access: yesGMS German Medical Science, 2014
[english] Aim: To study associations between health-related quality of life (HRQoL), frequency of illness, and weight in primary school children in southern Germany.
Kesztyüs, Dorothea   +7 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

An axiomatic approach to composite solutions [PDF]

open access: yes
We investigate a situation in which gains from cooperation are represented by a cooperative TU-game and a solution proposes a division of coalitional worths.
Claus-Jochen Haake, Dinko Dimitrov
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Appropriate Classification of Obesity in Mentally Retarded Adults [PDF]

open access: yes, 1983
Triceps skinfold thickness and body weight measures were obtained for 44 female and 40 male mentally retarded adults participating in a sheltered workshop setting.
Burkhart, Jennifer E.   +3 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Neck circumference as an alternative marker of metabolic syndrome in Peruvian adults: A retrospective, cross-sectional study

open access: yesEndocrine and Metabolic Science
Neck circumference is a low-cost and simple anthropometric measure that has been proven to accurately assess central obesity. However, evidence of its use and feasibility in low-resource settings is limited.
Virgilio E. Failoc-Rojas   +5 more
doaj   +1 more source

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