Results 91 to 100 of about 3,134,168 (295)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Comparison of the Happiness Level of Farmers at Suburban Villages with Farmers at Remotes Villages [PDF]

open access: yesBIO Web of Conferences
The study aims to analyze the level of happiness of farmers at two villages The research was conducted at X village, Pare sub-district, Kediri Regency (a suburban village), and Y village, Ngancar district, Kediri Regency (a village far from the city ...
Ibrahim Jabal Tarik   +4 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Trade Patterns and Welfare [PDF]

open access: bronze, 2005
Roberto A. De Santis, Frank Stähler
openalex   +1 more source

Cow welfare aspects in automatic milking systems [PDF]

open access: yes, 2004
This paper deals with the aspects of cow welfare in automatic milking systems, using literature and observations from the Suitia research farm and the first Finnish private farms.
Kaihilahti, Jutta, Raussi, Satu
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The Effect of Internal Marketing on the Prosperity of Maqashid Syariah Perspective Employees on Banking in Surakarta

open access: yesJournal of Islamic Economic Laws
This study aims to determine the effect of internal marketing consisting of the dimensions of the Company Mission and Development of Human Resources on the welfare of employees from the perspective of Maqashid Syariah on banking in the city of Surakarta.
Raisa Aribatul Hamidah   +1 more
doaj   +1 more source

Welfare to Work [PDF]

open access: yes, 2007
[Excerpt] This paper explores welfare to work policy in the UK and sets out ways in which the delivery of that policy could become more efficient and effective by making small but significant changes to the approach.
Scott-Parker, Susan
core   +1 more source

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