Results 91 to 100 of about 3,447,755 (405)

Does organic farming face distinctive livestock welfare issues? - A conceptual analysis [PDF]

, 2001
The recent development and growth of organic livestock farming and the related development of national and international regulations has fuelled discussions among scientists and philosophers concerning the proper conceptualisation of animal welfare ...
Alrøe, Hugo Fjelsted, Kristensen, Erik Steen, Vaarst, Mette   +2 more
core  

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

How does the introduction of ‘choice’ affect the pooling of risks in European welfare states? The case of long-term care [PDF]

, 2009
Ongoing reforms of European welfare states that aim at increasing ‘choice’ for patients, clients, and beneficiaries provide a unique opportunity to explore what exactly drives these reforms and how they reconstitute communities of economic risks ...
Costa-Font, Joan, Schelkle, Waltraud., van Wijnbergen, Christa   +2 more
core  

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Human-animal interactions and machine-animal interactions in animals under human care: A summary of stakeholder and researcher perceptions and future directions

Animal Welfare
Animals under human care are exposed to a potentially large range of both familiar and unfamiliar humans. Human-animal interactions vary across settings, and individuals, with the nature of the interaction being affected by a suite of different intrinsic
Ellen Williams, Jennifer Sadler, Steven Mark Rutter, Clara Mancini, Christian Nawroth, Joseph M Neary, Samantha J Ward, Gemma Charlton, Annabelle Beaver   +8 more
doaj   +1 more source

Insecurity and welfare [PDF]

, 2004
Using original survey data, we examine how insecurity affects welfare. Correcting for unobserved heterogeneity and possible endogeneity, we find an effect of insecurity on incomes, school enrolment, health status, and infant mortality. Results are robust to the inclusion of various shocks potentially affecting both welfare and insecurity.
Marcel Fafchamps, Bart Minten
openaire   +3 more sources

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Does tail docking prevent Cochliomyia hominivorax myiasis in sheep? A six-year retrospective cohort study

Animal Welfare
Tail docking is a husbandry practice widely incorporated in sheep farms around the world. It is an irreversible mutilation that impairs animal welfare, both immediately and in the longer term.
Giuliano Pereira de Barros, Maria José Hötzel, Marceli Carvalho da Silva, Laura Lívia Arias Avilés, Patrizia Ana Bricarello   +4 more
doaj   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

“Feelings and Fitness” Not “Feelings or Fitness”–The Raison d'être of Conservation Welfare, Which Aligns Conservation and Animal Welfare Objectives

Frontiers in Veterinary Science, 2018
Increasingly, human activities, including those aimed at conserving species and ecosystems (conservation activities) influence not only the survival and fitness but also the welfare of wild animals. Animal welfare relates to how an animal is experiencing
N. Beausoleil, D. Mellor, L. Baker, Sandra E. Baker, M. Bellio, A. Clarke, A. Dale, S. Garlick, B. Jones, Andrea Harvey, B. Pitcher, Sally L. Sherwen, K. Stockin, S. Zito   +13 more
semanticscholar   +1 more source