Results 101 to 110 of about 3,554,852 (355)
Qualitative certainty of the standard of living in the Omsk region [PDF]
Омский научный вестник: Серия "Общество. История. Современность"The main quality of a socially oriented economy is the achievement of the general welfare of the population, which implies ensuring a decent, comfortable and safe life.
T. I. Gordievich, P. V. Ruzanov
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Scientific Opinion on the use of animal‐based measures to assess welfare in pigs
EFSA Journal, 2012 Animal‐based measures, identified on the basis of scientific evidence, can be used effectively in the evaluation of the welfare of on‐farm pigs in relation to laws, codes of practice, quality assurance schemes and management.
EFSA Panel on Animal Health and Welfare (AHAW)
doaj +1 more source
Avant-garde Welfare Capitalism: Corporate Welfare Work and Enlightened Capitalism in Great Britain, the US, Germany and France (1880-1930) [PDF]
, 2014 This research paper deals with welfare work in four industrializing countries, Great Britain, the USA, Germany and France, in the half century of flowering enlightened paternalistic capitalism between 1880 and 1930.
de Gier, Erik
core +1 more source
Reducing Inefficiency in Carbon Auctions with Imperfect Competition [PDF]
, 2019 We study auctions for carbon licenses, a policy tool used to control the social cost of pollution. Each identical license grants the right to produce a unit of pollution.
Goldner, Kira +2 more
core +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Guidelines for the welfare and use of animals in cancer research
British Journal of Cancer, 2010 Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer.
P. Workman +19 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source