Results 121 to 130 of about 3,554,852 (355)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Behavioural decisions & welfare [PDF]
, 2010 If decision-makers (DMs) do not always do what is in their best interest, what do choices reveal about welfare? This paper shows how observed choices can reveal whether the DM is acting in her own best interest.
Dalton, Patricio S., Ghosal, Sayantan
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Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Journal of Islamic Economic LawsThis study aims to determine the effect of internal marketing consisting of the dimensions of the Company Mission and Development of Human Resources on the welfare of employees from the perspective of Maqashid Syariah on banking in the city of Surakarta.
Raisa Aribatul Hamidah +1 more
doaj +1 more source
Exploring Malta's welfare model [PDF]
, 2011 The paper compares the Maltese welfare state with other mainstream welfare regimes. It makes use of Esping-Andersen’s concepts of decommodification and stratification, whilst also looking at political and ideological factors.
Briguglio, Michael, Bugeja, Ian
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Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
IEEE AccessThe central focus of this study revolves around constructing a comprehensive load model to estimate the elasticity of electricity demand predicated on customers’ risk-averse tendencies.
Yaser A. Nanehkaran +4 more
doaj +1 more source
Measuring Social Welfare Gains in Social Assistance Programs: An Application to European Countries [PDF]
, 2019 This paper aims to provide a framework for a complete assessment of the overall welfare gains resulting from social assistance programs. We make use of a social welfare function that satisfies several properties that must be considered when measuring the
Ayala Cañón, Luis +1 more
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source