Results 141 to 150 of about 3,554,852 (355)

Effect of Group Mixing and Available Space on Performance, Feeding Behavior, and Fecal Microbiota Composition during the Growth Period of Pigs

open access: yesAnimals
Stress significantly affects the health, welfare, and productivity of farm animals. We performed a longitudinal study to evaluate stress’s effects on pig performance, feeding behavior, and fecal microbiota composition.
Adrià Clavell-Sansalvador   +9 more
doaj   +1 more source

$K$-anonymous Signaling Scheme [PDF]

open access: yes, 2013
We incorporate signaling scheme into Ad Auction setting, to achieve better welfare and revenue while protect users' privacy. We propose a new \emph{$K$-anonymous signaling scheme setting}, prove the hardness of the corresponding welfare/revenue ...
Chen, Binyi, Liu, Tie-Yan, Qin, Tao
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The Interface Between Veterinary and Behavioral Management of Chimpanzees (Pan troglodytes) in a United States Sanctuary Demonstrated by Two Clinical Cases

open access: yesVeterinary Sciences
Chimp Haven is a private, nonprofit organization that serves as the largest chimpanzee sanctuary in the world. The National Institutes of Health supports the federal sanctuary system, which is operated by Chimp Haven, to provide lifetime care for ...
Raven Jackson, Rebekah Lewis, Amy Fultz
doaj   +1 more source

Welfare to Work [PDF]

open access: yes, 2007
[Excerpt] This paper explores welfare to work policy in the UK and sets out ways in which the delivery of that policy could become more efficient and effective by making small but significant changes to the approach.
Scott-Parker, Susan
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Inequality, welfare and monotonicity [PDF]

open access: yes, 1997
We stablish a general relationship between the standard form of the individualistic social-welfare function and the "reduced-form" version that is expressed in terms of inequality and mean income.
Amiel, Yoram, Cowell, Frank
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

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