Results 91 to 100 of about 3,554,852 (355)

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Cow welfare aspects in automatic milking systems [PDF]

open access: yes, 2004
This paper deals with the aspects of cow welfare in automatic milking systems, using literature and observations from the Suitia research farm and the first Finnish private farms.
Kaihilahti, Jutta, Raussi, Satu
core  

Animal welfare in the reformed Common Agricultural Policy: wherefore art thou? [PDF]

open access: yes, 2015
Against the backdrop of the recently reformed Common Agricultural Policy (CAP), this article considers the potential for improved standards of farm animal welfare within the Treaty objectives of the European Union.
Ryland, Diane
core   +1 more source

Genetic selection of broilers and welfare consequences: a review

open access: yesWorlds Poultry Science Journal, 2019
SUMMARY The genetic selection of broilers over the past 60 years has focused narrowly and intensely on production traits, namely growth rate and feed efficiency.
K. Hartcher, H. Lum
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Enzootic bovine leukosis

open access: yesEFSA Journal, 2015
Enzootic bovine leukosis is a disease of cattle caused by bovine leukemia virus (BLV). The virus causes a persistent, life‐long infection in a subset of B cells.
EFSA Panel on Animal Health and Welfare (AHAW)
doaj   +1 more source

Operational Details of the Five Domains Model and Its Key Applications to the Assessment and Management of Animal Welfare

open access: yesAnimals, 2017
Simple Summary The Five Domains Model is a focusing device to facilitate systematic, structured, comprehensive and coherent assessment of animal welfare; it is not a definition of animal welfare, nor is it intended to be an accurate representation of ...
D. Mellor
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

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