Results 31 to 40 of about 31,092 (245)

L’invenzione come forma di resistenza. Le attrezzature, i servizi e la produzione nelle Alpi

open access: yesArchAlp, 2021
As Werner Bätzing (2003) points out in his book on Alpine geography, producers who do not emigrate and stay in the Alps do not act from an economic perspective but for social and cultural reasons.
Gabriele Salvia, Marion Serre
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Walking on Tiptoes: Digital Pads Deserve Increased Attention When Scoring Footpad Dermatitis as an Animal Welfare Indicator in Turkeys

open access: yesFrontiers in Veterinary Science, 2021
Animal welfare is one of the most challenging issues in modern farm animal husbandry. Animal welfare indicators can be used to monitor welfare on farms or at slaughterhouses, with footpad dermatitis (FPD) being one of the most important indicators used ...
Jenny Stracke   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

The Ruins of the British Welfare State

open access: yesFootprint, 2011
The subjects of Owen Hatherley’s A Guide to the New Ruins of Great Britain are architecture and urban development. The book addresses also some broader cultural, political and economic references, as well as personal anecdotes and memories.
Tahl Kaminer
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

The Rise of Welfare Service States - Conceptual challenges of an ambiguous welfare settlement and the need for new policy research

open access: yesSocial Work and Society, 2019
Welfare states are changing. They differ in the way they provide their citizenry with social rights, material resources and support. Contemporary transformations of European welfare states, however, have - apart from significant differences - a common ...
Jean-Michel Bonvin   +3 more
doaj   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

A Bibliography of Publications in Economic and Social History Printed in Poland in 1997-2000

open access: yesStudia Historiae Oeconomicae, 2006
Bibliography Methodology, theory and history of economic thought Sources and source studies General publications Demography Social structure and mobility Labour, social movements and trade unions Social and economic relations in rural communities Towns ...
Ewelina Kowal
doaj   +1 more source

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