Results 41 to 50 of about 275,752 (292)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Social Work and Society, 2019 Welfare states are changing. They differ in the way they provide their citizenry with social rights, material resources and support. Contemporary transformations of European welfare states, however, have - apart from significant differences - a common ...
Jean-Michel Bonvin +3 more
doaj +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
A Bibliography of Publications in Economic and Social History Printed in Poland in 1997-2000
Studia Historiae Oeconomicae, 2006 Bibliography Methodology, theory and history of economic thought Sources and source studies General publications Demography Social structure and mobility Labour, social movements and trade unions Social and economic relations in rural communities Towns ...
Ewelina Kowal
doaj +1 more source
Designing a product service system in a social framework: methodological and ethical considerations [PDF]
, 2009 Macroscopic social and economic changes in the last few years are forcing business companies and public institutions to redefine their approach to social intervention, focusing on local and highly individualised solutions. This change is also calling for
Jonas, Wolfgang +2 more
core
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Housing for the greatest number
Docomomo Journal, 2021 Addressing a broader vision, entitled “Housing for All”, this issue is dedicated to the welfare era, when governments across the world established ambitious housing programs to provide housing for the greatest number and improve the citizens’ living ...
Ana Tostões
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
ArchAlp, 2020 In both the South Tyrolean and Alpine areas, the case of Brunico is emblematic with regards to welfare strategies. Since the seventies and up to today, far-sighted planning policies have decisively contributed to their development.
Eleonora Gabbarini
doaj +1 more source