Results 111 to 120 of about 1,159,902 (301)

Uniform pricing and social welfare [PDF]

open access: yes
We re-examine the case for uniform pricing in a monopolistic third-degree price-discrimination setting by introducing differentiated costs. A profit-maximizing monopolist could then use price differentiation to reduce the production of the more costly ...
Bertoletti, Paolo
core   +1 more source

Vision of Dutch organic dairy farmers on animal health and welfare [PDF]

open access: yes, 2009
Dutch organic dairy farmers expressed their opinions on animal health and welfare in order to be able to communicate it internally (within the dairy sector) and externally (to consumers).
Bestman, M.W.P.   +2 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Australia-New Zealand Currency Union: A Structural Approach [PDF]

open access: yes
This paper compares an Australia-New Zealand currency union to a purely fl oating exchange rate regime in the context of a structural, two-country open economy model.
Daisy McGregor
core  

The process of researching animal health and welfare planning [PDF]

open access: yes, 2009
’Minimising medicine use in organic dairy herds through animal health and welfare planning’, ANIPLAN, is a CORE-Organic project which was initiated in June 2007.
Brinkmann, Jan   +6 more
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Psychological Research in Iran: Review the Structure of Scientific Research Articles

open access: yesمجله علوم روانشناختی, 2018
Background: Several studies indicate that the structure of scientific articles in Phycology, particularly in methodology, have not met the required scientific standards.
Susan Rahimzadeh   +3 more
doaj  

Infrared Thermography and Physiological Variables as Methods for Recognizing Fear in Domestic Cats (Felis catus) Using Three Pharmacological Models: Cannabidiol, Gabapentin, and Synthetic Facial Pheromones

open access: yesVeterinary Sciences
This study aimed to assess changes in the surface temperature and physiological parameters of cats exposed to a fear model involving negative dog–cat interactions, receiving three pharmacological options: a single dose of cannabidiol, gabapentin, or ...
Fabiola Torres-Bernal   +8 more
doaj   +1 more source

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