Results 161 to 170 of about 2,883,415 (350)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Efficient social policies with higher expenditure: an analysis for European countries [PDF]

open access: yes, 2018
Based on the construction of two indicators to assess the relative effectiveness and efficiency of European welfare policies, we show that the variability of efficiency cannot be explained only by the amount of resources devoted to social policies but
Antonelli, MARIA ALESSANDRA   +1 more
core  

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

The accounting innovation by welfare indicators

open access: yes, 2018
La ricerca intende individuare quali indicatori sociali rispondano meglio al bisogno di trasparenza e conoscenza dei cittadini nel percorso deliberativo e come essi incidono nell’accountability per l’azienda pubblica locale. In particolare, ci si domanda se gli indicatori sociali siano in grado di garantire una maggiore consapevolezza del contesto in ...
Paolo Biancone   +2 more
openaire   +3 more sources

Remittances, Trade Liberalisation, and Poverty in Pakistan : The Role of Excluded Variables in Poverty Change Analysis [PDF]

open access: yes
This study attempts to assess the impact of two shocks - trade liberalisation and a decline in remittances from abroad- on poverty in Pakistan using a CGE framework.
A. R. Kemal, Rizwana Siddiqui
core   +1 more source

Indikatoren für eine ergebnisorientierte Honorierung von Tierschutzleistungen in der Milchviehhaltung [PDF]

open access: yes, 2015
Regulations in organic farming and in animal welfare policies are action-oriented: they refer to resources such as space allowance and management, i.e. access to pasture.
Bergschmidt, Angela   +6 more
core  

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Graduate Student Literature Review: Integrating concepts of animal welfare and health-related quality of life for preweaning dairy calves*

open access: yesJournal of Dairy Science
: Dairy calf welfare assessment tools focusing on the preweaning period have been proposed in recent research. Despite the existence of these tools, assessing the welfare and health-related quality of life (HRQoL) of dairy calves remains challenging ...
Jean Ramos   +6 more
doaj   +1 more source

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