Results 61 to 70 of about 1,219,423 (282)

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Achieving Quality Services: A Checklist for Evaluating Your Agency [PDF]

open access: yes, 2002
[Excerpt] In recent years, several trends have led state service systems to focus more directly on employment as an expected outcome of service delivery for many individuals who have traditionally experienced difficulty in successfully maintaining ...
Institute for Community Inclusion
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Ultrastructural organization and reproduction of virions in Vero (E6) cells in influenza A/H1N1 pmd09 virus monoinfection and coinfection with SARS-CoV-2 (Delta and Omicron strains)

open access: yesВопросы вирусологии
Introduction. RNA-containing viruses, especially influenza viruses, are of high epidemiological significance. The manifestation of COVID-19 has led to the registration of coinfection cases, the pathogenesis of which is poorly studied.
Ksenia F. Emtsova   +5 more
doaj   +1 more source

The Organization of Public Service Provision [PDF]

open access: yes
This paper addresses the question of how the responsibility for the delivery of social services, including health, education, and welfare programs, should be divided between state and central governments.
Billy Jack
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

The results of epidemiological analysis of salmonellosis incidence in the Rostov region under current conditions

open access: yesМедицинский вестник Юга России
Objective: to study the features of the epidemic process of salmonella infection under current conditions. To establish a causal relationship between the incidence of salmonellosis and the functioning of public catering enterprises, which can form the ...
E. V. Kovalev   +10 more
doaj   +1 more source

General Principles of Good Governance in Indonesia: What are The Legal Bases?

open access: yesVaria Justicia, 2019
The concept of a welfare state starts from many typical countries, namely the Police State (Polizei Staat), the State of Formal Law (Liberal) and the State of Material Law (Welvaarstaat / welfare state).
M. Zamroni
doaj   +1 more source

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