Results 61 to 70 of about 1,221,165 (304)

The Organization of Public Service Provision [PDF]

open access: yes
This paper addresses the question of how the responsibility for the delivery of social services, including health, education, and welfare programs, should be divided between state and central governments.
Billy Jack
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Quantifying the benefits of entry into local phone service [PDF]

open access: yes, 2007
Local telecommunications competition was an important goal of the 1996 Telecommunications Act. We evaluate the consumer welfare effects of entry into residential local telephone service in New York State using household-level data from September 1999 to ...
Economides, Nicholas - NYU Stern School of Business   +2 more
core  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

Ultrastructural organization and reproduction of virions in Vero (E6) cells in influenza A/H1N1 pmd09 virus monoinfection and coinfection with SARS-CoV-2 (Delta and Omicron strains)

open access: yesВопросы вирусологии
Introduction. RNA-containing viruses, especially influenza viruses, are of high epidemiological significance. The manifestation of COVID-19 has led to the registration of coinfection cases, the pathogenesis of which is poorly studied.
Ksenia F. Emtsova   +5 more
doaj   +1 more source

New labour and reform of the English NHS: user views and attitudes. [PDF]

open access: yes, 2009
BACKGROUND: The British National Health Service has undergone significant restructuring in recent years. In England this has taken a distinctive direction where the New Labour Government has embraced and intensified the influence of market principles ...
Taylor-Gooby, Peter, Wallace, Andrew
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

General Principles of Good Governance in Indonesia: What are The Legal Bases?

open access: yesVaria Justicia, 2019
The concept of a welfare state starts from many typical countries, namely the Police State (Polizei Staat), the State of Formal Law (Liberal) and the State of Material Law (Welvaarstaat / welfare state).
M. Zamroni
doaj   +1 more source

Corporate social responsibility in the first years of Caja de Pensiones para la Vejez y de Ahorros [PDF]

open access: yes
When Caja de Pensiones para la Vejez y de Ahorros, 'la Caixa', was created in 1905, it was not just a transient response to a serious social, political, and economic problem; it also provided a permanent solution by creating a long-lasting social welfare
Argandoña, Antonio   +2 more
core  

Recent trends for social enterprises in the United Kingdom [PDF]

open access: yes, 2013
In this presentation I want to provide you with a picture of some of the trends that are developing for social enterprises in the United Kingdom (U.K.). Social enterprise are becoming an increasingly important part of the U.K.
Durkin, Chris
core  

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