Results 51 to 60 of about 1,097,065 (304)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Productivity, welfare and reallocation : theory and firm-level evidence [PDF]
A considerable literature has focused on the determinants of total factor productivity (TFP), prompted by the empirical finding that TFP accounts for the bulk of long-term growth.
Basu, Susanto +3 more
core +3 more sources
Piracy of Digital Products: A Contest Theoretical Approach [PDF]
, 2007 In the following, we examine a market of a digital consumption good with monopolistic supply. In this market, it is the ability of the consumer to bypass (”crack”) the copy-protection of the monopolist which induces a lower price of the digital good ...
Hoffmann, Magnus, Schmidt, Frederik
core +2 more sources
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
BMC Health Services Research, 2023 Background Health and welfare technologies (HWT) are increasingly procured and implemented by public providers in Swedish municipalities, but it remains unclear if and how evidence for these technologies’ effectiveness is used in both processes.
Matt X. Richardson +1 more
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Silicon Valley versus Corporate Welfare [PDF]
, 1998 The estimated $65 billion a year that the federal government now spends on corporate welfare programs harms U.S. industry in general and Silicon Valley companies in particular.
T. J. Rodgers
core
Standards, Innovation Incentives, and the Formation of Patent Pools [PDF]
, 2010 Technological standards give rise to a complements problem that affects pricing and innovation incentives of technology producers. In this paper I discuss how patent pools can be used to solve these problems and what incentives patent holders have to ...
Schmidt, Klaus M.
core +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Welfare Technologies and Ageing Bodies: Various Ways of Practising Autonomy [PDF]
Rehabilitation Research and Practice, 2018 Contemporary policy strategies frame welfare technologies as a solution for welfare states facing the challenges of demographic change. Technologies are supposed to reduce or substitute the work of care workers and thereby reduce attrition among their ranks, reduce costs, and at the same make elderly people self-reliant and independent.
openaire +4 more sources