Results 41 to 50 of about 1,242,988 (308)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Measurement of the Agrarian Sector Performance with Account of the Recommendations of Stiglitz Commission

Статистика України, 2015
The social welfare in Ukraine is measured by territorial location of the population (rural and municipal), which is required for the even extended reproduction of human capital and comprehensive development of a human with account for social issues ...
K. O. Prokopenko, L. O. Udova
doaj  

National Identity and Public-Welfare Behavior Among Chinese Adolescents A Mediated Moderation Model

European Journal of Psychology Open, 2023
: Introduction: Public-welfare behavior is a special prosocial behavior. Actively participating in public welfare activities has an important impact on the psychological development of adolescents.
Danyun Wang, Yuting Tang, Yulong Wang
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The Role of Agency and Institutional Theory in the Planning and Realization for Capital Expenditures

Jurnal Dinamika Akuntansi, 2017
The capital expenditures are part of direct expenditure in the regional budget. The other elements of capital expenditures are: personnel expenditure, and spending on goods and services.
Syaiful Hifni
doaj   +1 more source

Theological proposals to the welfare state theory: The contribution of the Evangelical Church in Germany

HTS Teologiese Studies/Theological Studies, 2022
Establishing the aims and objectives of a welfare state is an integral part of the political, economic and cultural debate, in particular, the repercussions of a welfare state on economic systems and social institutions; the sociopsychological ...
Piotr Kopiec
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The Big Society and the Conjunction of Crises: Justifying Welfare Reform and Undermining Social Housing [PDF]

, 2014
The idea of the “Big Society” can be seen as culmination of a long-standing debate about the regulation of welfare. Situating the concept within governance theory, the article considers how the UK coalition government has justified a radical ...
Atkinson R., Bevir M., Blond P., Boles N., Chhotray V., CLG (Communities and Local Government), Conservative Party, Cruikshank B., CSJ (Centre for Social Justice), CSJ (Commission for Social Justice), Davies J., Davies J., Dean M., Dillon D., Durose C., DWP (Department of Work and Pensions), Etzioni A., Flinders M., Flint J., Foucault M., Gamble A., Giddens A., Gross J., Harris J., HM Government, Home Office, Huntingdon S., Hutton W., Huxham C., Ipsos MORI, Jenkins S., Jessop B., Jessop B., Jessop B., John P., Jones O., Lowndes V., Massey D., Mulliner E., Murray C., Norman J., Oakeshott M., Pawson H., Rennard C., Rhodes R., Schattschneider E., Stoker G., Stoker G., Taylor M., Taylor M., Thaler R., Tony Manzi, Travers T.   +52 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Qur’anic Models for Social Welfare Policy: Insights from Prophet Yusuf and Zulkarnain in Addressing Indonesian Social Justice Challenges

Jurnal Sosiologi Agama Indonesia
Indonesia’s diverse society faces persistent challenges from environmental uncertainty and social conflict, which threaten both economic security and social cohesion.
Alif Hibatullah, Muh. Niam
doaj   +1 more source