Results 51 to 60 of about 6,115,484 (302)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Local government performance as a mediator between institutional capacity and community welfare in Jambi Province

Jurnal Perspektif Pembiayaan dan Pembangunan Daerah
Fiscal decentralization is intended to improve community welfare by strengthening local governments' fiscal capacity, organizational characteristics, and bureaucratic human resources.
Iskandar Sam, Haryadi Haryadi, Sri Rahayu, Wirmie Eka Putra, Sumarni Sumarni   +4 more
doaj   +1 more source

Classifying theories of welfare [PDF]

Philosophical Studies, 2012
This paper argues that we should replace the common classification of theories of welfare into the categories of hedonism, desire theories, and objective list theories. The tripartite classification is objectionable because it is unduly narrow and it is confusing: it excludes theories of welfare that are worthy of discussion, and it obscures important ...
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Other title: Report of the chief juvenile court probation officer of the state of Connecticut for ...; Other title: Volume for 1940 has title: Connecticut children in court : the report of the Legislative Council of the state of Connecticut for the fiscal year ending ... and the calendar year ending ...

, 1931
Annual; Report year varies; issue for calendar year ending 1940 includes fiscal year ending June 30, 1940.; Volumes for 1931-1933 issued by the Bureau of Child Welfare; volumes for 1934- by the Office of Commissioner of ...
Connecticut. Bureau of Child Welfare.
core   +1 more source

Inequalities in US Child Protection: The Case of Sex Trafficked Youth

Social Sciences, 2018
This article demonstrates how structural social work theory and critical consciousness development can be used to help facilitate a transition from a deficit model approach to an inequities perspective in a child welfare system that was working to ...
Lisa Werkmeister Rozas, Jason Ostrander, Megan Feely   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Citizen Participation at National Science and Technology Conference: A Case of Geriatric Welfare [PDF]

Applied Research in Administrative Sciences
According to the National Development Council's estimates, Taiwan will become a super-aged society in 2025, and geriatric welfare will become an essential issue.
Chao, JIUN-CHUAN
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Welfare Theory: History and Modern Results [PDF]

This paper contains a fairly brief, but self-contained, version of the history of welfare economics, as well as the more modern welfare results. We introduce public goods and asymmetric information, and we hint at some of the modern mechanism design ...
Löfgren, Karl-Gustaf, Aronsson, Thomas
core