Results 141 to 150 of about 18,696,266 (312)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Dimensions of Well-being and the Millennium Development Goals [PDF]
Well-being and happiness, individually and collectively, is a main indicator of a good life. This paper attempts to implement empirically some of the multidimensional concepts of human well-being by using data from the ‘Pakistan Living Standards ...
Uzma Zia, Rashida Haq
core
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Shaping smart tourism: a bibliometric and benchmarking analysis of IoT trends
Discover Internet of ThingsThis work aims to analyze the emerging trends in IoT (Internet of Things) and how they can shape the future of the tourism sector. It uses the tool Biblioshiny for a bibliometric analysis on the Web of Science and a benchmarking exercise for a comparison
Sílvia Fernandes, Fátima Carvalho
doaj +1 more source
Workaholism and Employee Well-Being
, 2011 The term workaholism, patterned after the word alcoholism, first appeared in a book by Oates (1971) in which he described workaholism as a compulsive or uncontrollable need to work incessantly, resulting in negative consequences.
Horton, Tanya Elizabeth
core
Priming and the reliability of subjective well-being measures [PDF]
, 2010 Economists and behavioural scientists are beginning to make extensive use of measures of subjective well-being, and such data are potentially of value to policy-makers.
Dobson, Alexander +3 more
core
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
ENVIRONMENTAL SURROUNDINGS AND PERSONAL WELL-BEING IN URBAN CHINA [PDF]
We examine the relationship between atmospheric pollution, water pollution, traffic congestion, access to parkland and personal well-being using a survey administered across six Chinese cities in 2007.
Zhihong Wang +8 more
core +2 more sources