Results 61 to 70 of about 6,879,798 (323)

Bayesian Model Selection Based on Proper Scoring Rules

, 2015
Bayesian model selection with improper priors is not well-defined because of the dependence of the marginal likelihood on the arbitrary scaling constants of the within-model prior densities.
Dawid, A. Philip, Musio, Monica
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Anomaly Detection in Log Data using Graph Databases and Machine Learning to Defend Advanced Persistent Threats

, 2017
Advanced Persistent Threats (APTs) are a main impendence in cyber security of computer networks. In 2015, a successful breach remains undetected 146 days on average, reported by [Fi16].With our work we demonstrate a feasible and fast way to analyse real ...
Schindler, Timo
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Machine Learning in Electrofacies Classification and Subsurface Lithology Interpretation: A Rough Set Theory Approach

Applied Sciences, 2020
Initially, electrofacies were introduced to define a set of recorded well log responses in order to characterize and distinguish a bed from the other rock units, as an advancement to the conventional application of well logs.
Touhid Mohammad Hossain, Junzo Watada, Izzatdin A. Aziz, Maman Hermana   +3 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

DISCRIMINACIÓN DE GAS COMERCIAL Y GAS FIZZ MEDIANTE ANÁLISIS DE ATRIBUTOS AVO Y MODELADO DE SUBSTITUCIÓN DE FLUIDOS

Revista Fuentes El Reventón Energético, 2019
The Analysis of the AVO attributes based on geophysics models, rock physics and seismic modeling, has become an important tool in the study of the exploration projects, helping to recognize zones with possible commercial interest.
Andres Eduardo Calle Ochoa, César Augusto Pineda Gómez, Lorena Giraldo   +2 more
doaj  

Typification of the deposits of the Tyumen Formation according to the degree of hydrodynamic conditions of sedimentation to create a petrophysical model and differentiated interpretation of well log data

Georesursy
The article considers facies analysis and the application of its results for the typification of rocks of the Tyumen Formation. The aim of the article is to create algorithms for the differentiated interpretation of geophysical studies of well log data ...
T. G. Isakova, A. S. Persidskaya, O. V. Khotylev, J. A. Kotochkova, A. D. Egorova, T. F. Dyakonova, A. S. Mozgovoy, V. V. Churkina, S. V. Kozakov, N. V. Kozhevnikova, R. Z. Livaev, V. S. Druchin, N. V. Belov, G. A. Kalmykov   +13 more
doaj   +1 more source