Results 81 to 90 of about 6,879,798 (323)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Stock market crashes, Precursors and Replicas

, 1995
We present an analysis of the time behavior of the $S\&P500$ (Standard and Poors) New York stock exchange index before and after the October 1987 market crash and identify precursory patterns as well as aftershock signatures and characteristic ...
Bouchaud, Jean-Philippe, Johansen, Anders, Sornette, Didier   +2 more
core   +7 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Seismic and geomechanical characterization of Asmari formation using well logs and simultaneous inversion in an Iranian oil field

Scientific Reports
This paper presents a case study on the application of simultaneous inversion (SI) technique and well log analysis to accurately seismic-geomechanical characterization of Asmari formation in an Iranian oil field.
Ahsan Leisi, Navid Shad Manaman
doaj   +1 more source

APPLICATION OF WELL LOG ANALYSIS IN ASSESSMENT OF PETROPHYSICAL PARAMETERS AND RESERVOIR CHARACTERIZATION OF WELLS IN THE “OTH” FIELD, ANAMBRA BASIN, SOUTHERN NIGERIA

International Journal of Science and Engineering, 2015
Over the past years, the Anambra basin one of Nigeria’s inland basins has recorded significant level of hydrocarbon exploration activities. The basin has been confirmed by several authors from source rock analyses to have the potential for generating ...
Eugene URORO, Efe Lucky IGHARO
doaj   +1 more source

Straight-line programs with memory and matrix Bruhat decomposition

, 2013
We advocate that straight-line programs designed for algebraic computations should be accompanied by a comprehensive complexity analysis that takes into account both the number of fundamental algebraic operations needed, as well as memory requirements ...
Niemeyer, Alice C., Popiel, Tomasz, Praeger, Cheryl E.   +2 more
core  

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Characterization of well logs using K-mean cluster analysis

Journal of Petroleum Exploration and Production Technology, 2020
The identification process of different lithologies, hydrocarbons, and water-saturated zones in oil and gas industries involves petrophysical studies that are carried out by geoscientists using different software packages.
Amjad Ali, Chen Sheng-Chang
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source