Results 61 to 70 of about 14,315,169 (231)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Frontiers in Energy Research, 2020 In order to solve the low recharge efficiency of middle and deep geothermal Wells, a thermo-hydro-mechanical (THM) model integrating geothermal production and reinjection was established, and the relationship model between recharge efficiency and ...
Song Deng +5 more
doaj +1 more source
Does child spacing affect children’s outcomes? Evidence from a Swedish reform [PDF]
In this paper, we provide evidence of whether child spacing affects the future success of children. As an exogenous source of variation in child spacing, we make use of the introduction of an administrative rule in the parental leave benefit system in ...
Skogman Thoursie, Peter +1 more
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Energies, 2020 At present, investigation of the effects of natural fractures on optimal well spacing of shale gas reservoirs from an economic perspective has been lacking.
Cheng Chang +5 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Birth Spacing, Child Survival and Fertility Decisions: Analysis of Causal Mechanismsa [PDF]
: We jointly analyze infant mortality, birth spacing, and total fertility of children in a rural area in Bangladesh, using longitudinal data from the Health and Demographic Surveillance System (HDSS) in Matlab.
Saha, U.R., Soest, A.H.O. van
core
Greater understanding of spacing needs for children’s eye movements during on-screen reading is required [PDF]
, 2009 This paper endeavors to consolidate current knowledge and empirical research concerning the use of typography for children’s on-screen reading. This paper is not intended as a full literature review, but attempts to raise awareness of the areas required ...
Vanderschantz, Nicholas
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source