Results 71 to 80 of about 15,623,747 (237)
Specialized face perception mechanisms extract both part and spacing information: evidence from developmental prosopagnosia [PDF]
, 2006 It is well established that faces are processed by mechanisms that are not used with other objects. Two prominent hypotheses have been proposed to characterize how information is represented by these special mechanisms.
Galit Yovel +3 more
core
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
An integrated assisted history matching and embedded discrete fracture model workflow for well spacing optimization in shale gas reservoirs [PDF]
, 2021 An appropriate well spacing plan is critical for the development of shale reservoirs. The biggest challenge for well spacing optimization is interpreting the subsurface uncertainties associated with hydraulic and natural fractures.
Li, Qiwei, M.S. in Engineering
core +1 more source
A mixed integer optimization strategy for oil and gas production planning [PDF]
, 2008 Oil and gas production is the cornerstone of the modern petrochemical industry, and its upstream as well as downstream processing provides many challenges to the process modeling, optimization and control areas.
Pistikopoulos, Efstratios N. +1 more
core
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Unconventional ResourcesThe exploration of sweet spots in the Jimsar shale oil reservoir in Xinjiang involves creating a complex fracture network through three-dimensional well networks and advanced fracturing technology, crucial for successful shale oil reservoir development ...
Shuiqing Hu +8 more
doaj +1 more source