Results 171 to 180 of about 17,521,233 (323)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Evaluation of the Wells score in predicting the incidence of stroke-associated pneumonia: the REMISE study. [PDF]

Front Neurol
Yu J, Liu Y, Chen J, Sun Q, Zhang W, Li D, Zhong Y, Wu Q, Wan Z.   +8 more
europepmc   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Spatial and Vertical Stratification of Groundwater Microbial Communities Reveals Proteobacterial Dominance and Redox-Driven Ecological Transitions. [PDF]

Microorganisms
Aljuaid RS, Alshareef SA, Jamal BT, Dhafeer FH, Alnahari AA, Ashy RA.   +5 more
europepmc   +1 more source

A review of fracturing fluid systems used for hydraulic fracturing of oil and gas wells

, 2014
R. Barati, Jenn-Tai Liang
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Residential proximity to active and abandoned oil and gas development and risk of childhood Ewing sarcoma in California. [PDF]

Environ Health
Clark CJ, Johnson N, Wang R, Stewart EC, Spector LG, Wiemels JL, Metayer C, Deziel NC, Ma X.   +8 more
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Per- and polyfluoroalkyl substances in waters associated with oil and gas development in the Denver Basin. [PDF]

Sci Rep
Varonka MS, Jubb AM, McDevitt B, Shelton JL, Barnhart EP, Akob DM, Cozzarelli IM.   +6 more
europepmc   +1 more source

Noble gases identify the mechanisms of fugitive gas contamination in drinking-water wells overlying the Marcellus and Barnett Shales

Proceedings of the National Academy of Sciences of the United States of America, 2014
T. Darrah, A. Vengosh, R. Jackson, N. Warner, R. Poreda   +4 more
semanticscholar   +1 more source