Results 171 to 180 of about 8,375 (258)

Phenotypic Variability and Paternal Inheritance of a CHD8 Variant Causing Intellectual Developmental Disorder With Autism and Macrocephaly Confirmed by Epigenetic and Structural Analyses. [PDF]

Mol Genet Genomic Med
Furuta Y, Ezell KM, Hamid R, Cogan JD, Cassini TA, Rives L, McMinn A, Shah S, Peltier AC, Layfield S, Fletcher RS, Tedder ML, Louie RJ, Lee JA, Kerkhof J, Rzasa J, Sadikovic B, Al Mamun A, Sheehan JH, Moth CW, Meiler J, Vawter-Lee M, Mendoza-Sengco PM, Holzen JB, Pruthi S, Phillips JA, Tinker RJ, Undiagnosed Diseases Network.   +27 more
europepmc   +1 more source

Human IgE Antibodies Recognize the Vicilin and Alpha‐Hairpinin Domains of Peanut Allergen Ara h 1

Allergy, EarlyView.
The ɑ‐hairpinin of Ara h 1 contains a dominant epitope that is both frequently recognized and blocks a majority of the IgE against this domain. Including this region in tests may improve diagnosis of peanut allergy. The trimeric structure of the vicilin region explains the ability of Ara h 1 to induce anaphylaxis with a single antibody.
Taylor M. Cosey, Gage O. Leighton, Emmanuel R. De Diavoukana, Min Shi, Alexander C. Y. Foo, Anna Pomés, Jacqueline B. Nesbit, Stephen A. Y. Gipson, Paige Creeks, Jian Zhang, R. Stokes Peebles, Soheila J. Maleki, Derek Croote, Scott A. Smith, Geoffrey A. Mueller   +14 more
wiley   +1 more source

Response to Letter to the Editor: Breast Cancer is Increased in Women With Primary Ovarian Insufficiency.

J Clin Endocrinol Metab
Allen-Brady K, Johnstone EB, Welt CK.
europepmc   +1 more source

[Doping: caught between fraud, health protection, and responsibility]. [PDF]

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
Koch-Gromus U.
europepmc   +1 more source

Pre‐Seasonal Treatment With Recombinant Carrier‐Based Birch Vaccine Improves Birch Pollen Allergy

Allergy, EarlyView.
We conducted a two stage SCIT trial with GNR‐127 containing a recombinant fusion protein consisting of Bet v 1 and Mal d 1‐derived peptides fused to PreS from HBV. Stage 1 identified two safe maximum tolerated doses (40 μg and 80 μg). In the following Stage 2, five preseasonal injections were well tolerated, induced dose‐dependent allergen‐specific IgG,
Musa R. Khaitov, Maria G. Byazrova, Evgenii V. Smolnikov, Vladislav N. Turenko, Valeriy V. Smirnov, Igor P. Shilovskii, Nadezhda N. Shershakova, Ekaterina N. Medunitsyna, Olga G. Elisyutina, Mikhail V. Pashenkov, George B. Pasikhov, Vladimir V. Murugin, Veronika A. Parshina, Darya K. Bolyakina, Anastasia S. Primak, Mariya A. Lapyko, Inna V. Danilycheva, Rosalia V. Schubelko, Anastasia A. Tsyvkina, Nataliia V. Shartanova, Daria O. Timoshenko, Irina I. Isakova, Tatiana V. Latysheva, Andrey E. Shulzhenko, Elena A. Latysheva, Oksana M. Kurbacheva, Elena S. Fedenko, Oksana A. Markova, Ilya A. Korotkevich, Violetta V. Yan, Natalia A. Gavrilova, Mariia V. Tikhomirova, Ivan V. Shevchenko, Alena A. Agafonova, Gregory N. Poroshin, Dmitry A. Kudlay, Alexander V. Filatov, Evgeniya V. Nazarova, Daria S. Kruchko, Dmitriy V. Goryachev, Vadim A. Merkulov, Nataliya I. Ilina, Rudolf Valenta, Veronica I. Skvortsova   +43 more
wiley   +1 more source

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

Allergy, EarlyView.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz, Salvador Iborra, Carlos Blanco, Ruperto González‐Pérez, Emilio Nuñez‐Borque, Can Zeyneloglu, Huseyn Babayev, Ozlem Göksel, Tuncay Göksel, Musa Khaitov, Dmitry Kudlay, Yadong Gao, Mustafa Sevim, Marie‐Charlotte Brüggen, Oral Alpan, Ming Wang, Luo Zhang, María J. Torres, Mohamed Shamji, Mübeccel Akdis, Kari C. Nadeau, Ismail Ogulur, Cezmi A. Akdis   +22 more
wiley   +1 more source

Divergent Regulatory and Reimbursement Pathways for Digital Therapeutics: A Scoping Review With Implications for Korea. [PDF]

Inquiry
Kim M, Kim G.
europepmc   +1 more source

IgE Sensitization Patterns of Mothers and Their Offspring in the First Five Years of Life The CHILD Study

Allergy, EarlyView.
The spectrum of allergic sensitization in mothers and their offspring was characterized at ages 1–5 years at an extract‐ and molecular level in a North American birth cohort. Fel d 1 was the primary sensitizer in mothers, followed by Phl p 1. Perennial allergen sensitization (Der f 1, Der p 1) was rare at age one but rose sharply by age five.
Mary Asumta Anyango Kodydek, Myrtha E. Reyna, Akash Kothari, Mikhail Monteiro, Jennifer A. Hoang, Kristen Ericka San Diego, Aimee Dubeau, Lisa Hung, Xiaojun Yin, Elinor Simons, Stuart E. Turvey, Piushkumar J. Mandhane, Padmaja Subbarao, Theo J. Moraes, Thomas Eiwegger   +14 more
wiley   +1 more source

[Genealogy, breeding and (bio)politics. The History of Knowledge and the Formation of Racial Discourse in the Early Modern and Modern Periods]. [PDF]

NTM
Lettow S.
europepmc   +1 more source

Dupilumab in Cholinergic Urticaria: An Exploratory Phase 2 Investigator‐Initiated Study

Allergy, EarlyView.
Annika Gutsche, Weronika Grabowska, Sabine Altrichter, Eva Grekowitz, Stephanie Roll, Guido Heine, Petra Staubach, Wolfgang Pfützner, Randolf Brehler, Andrea Bauer, Nicola Wagner, Gerda Wurpts, Pascale Salameh, Ali Salehzadeh‐Yazdi, Samad S. Jahandideh, Martin Metz   +15 more
wiley   +1 more source