Results 161 to 170 of about 21,295 (232)

Development of an exon 27-skipping antisense oligonucleotide as a targeted therapy for refractory skin ulcers in Werner syndrome. [PDF]

Mol Ther Nucleic Acids
Man Z, Asano S, Kakutani T, Kiyoshi A, Hino K, Ikeda A.   +5 more
europepmc   +1 more source

Targeting the Werner syndrome protein in microsatellite instability cancers: mechanisms and therapeutic potential. [PDF]

Clin Exp Med
Chen S, Wang Z, Cao Z, Xu M, Zhang Y.
europepmc   +1 more source

Lifetime extension and the recent cause of death in Werner syndrome: a retrospective study from 2011 to 2020. [PDF]

Orphanet J Rare Dis, 2022
Kato H, Koshizaka M, Kaneko H, Maezawa Y, Yokote K.   +4 more
europepmc   +1 more source

A Rare Cause of Acute Pancreatitis: Two Siblings With Werner Syndrome. [PDF]

JCEM Case Rep
Sakar K, Akinci B, Simsir IY, Atik T, Akbaba G, Cinar N.   +5 more
europepmc   +1 more source

MUT-7 Provides Molecular Insight into the Werner Syndrome Exonuclease. [PDF]

Cells, 2021
Hsu TY, Hsu LN, Chen SY, Juang BT.
europepmc   +1 more source

Less frequent skin ulcers among patients with Werner syndrome treated with pioglitazone: findings from the Japanese Werner Syndrome Registry. [PDF]

Aging (Albany NY)
Aono K, Koshizaka M, Shoji M, Kaneko H, Maeda Y, Kato H, Maezawa Y, Miyabayashi M, Ishikawa M, Sekiguchi A, Motegi SI, Tsukamoto S, Taniguchi A, Shoda Y, Yoshimura T, Kawashima J, Yoshinaga K, Nakagami H, Takami Y, Sugimoto K, Hashimoto K, Okubo N, Yoshida T, Ohara M, Kogure A, Suzuki D, Kuzuya M, Watanabe K, Takemoto M, Oshima J, Yokote K.   +30 more
europepmc   +1 more source

Renal dysfunction, malignant neoplasms, atherosclerotic cardiovascular diseases, and sarcopenia as key outcomes observed in a three-year follow-up study using the Werner Syndrome Registry. [PDF]

Aging (Albany NY), 2023
Maeda Y, Koshizaka M, Shoji M, Kaneko H, Kato H, Maezawa Y, Kawashima J, Yoshinaga K, Ishikawa M, Sekiguchi A, Motegi SI, Nakagami H, Yamada Y, Tsukamoto S, Taniguchi A, Sugimoto K, Takami Y, Shoda Y, Hashimoto K, Yoshimura T, Kogure A, Suzuki D, Okubo N, Yoshida T, Watanabe K, Kuzuya M, Takemoto M, Oshima J, Yokote K.   +28 more
europepmc   +1 more source

Werner syndrome - Telomere maintenance and replication processes underlying Werner syndomre

, 2008
Werner syndrome is a syndrome which accelerates the normal aging process of an individual. The Syndrome is caused by mutations in the WRN gene. The precise link between this mutated gene and the phenotype is still unclear but much science has been done ...
Larsen, Frederik Weile
core  

Targeting Werner Syndrome Helicase with Small Molecules in Mismatch Repair-Deficient Cancers. [PDF]

ACS Med Chem Lett
Kargbo RB.
europepmc   +1 more source

Targeted long-read sequencing identifies missing pathogenic variants in unsolved Werner syndrome cases. [PDF]

J Med Genet, 2022
Miller DE, Lee L, Galey M, Kandhaya-Pillai R, Tischkowitz M, Amalnath D, Vithlani A, Yokote K, Kato H, Maezawa Y, Takada-Watanabe A, Takemoto M, Martin GM, Eichler EE, Hisama FM, Oshima J.   +15 more
europepmc   +1 more source