Results 81 to 90 of about 19,449 (186)
WRN regulates pathway choice between classical and alternative non-homologous end joining
Nature Communications, 2016 Werner Syndrome is an accelerated aging disorder marked by genome instability, large deletions and telomere fusions, hallmarks of aberrant DNA repair.
Raghavendra A. Shamanna +5 more
doaj +1 more source
Psychophysiology, Volume 63, Issue 9, September 2026.ABSTRACT Placebo pills reliably reduce pain. Pain perception is tied to increased arousal and heart rate. Heart rate perception is, in turn, closely related to interoceptive signals processing, for example, pain and autonomic regulation. However, no studies so far have systematically examined the generalizing versus specific effects of placebo ...
Helena Hartmann +3 more
wiley +1 more source
Nonlinearities and Switch‐Like Behavior in Gene Expression: From Genetics to Biochemistry and Back
The FASEB Journal, Volume 40, Issue 16, 31 August 2026.Modest changes in transcription‐factor or chromatin‐regulator dosage can have disproportionate effects when gene‐regulatory systems operate near nonlinear thresholds. Sigmoidal input–output relationships, chromatin and cofactor recruitment, and changes in threshold position or response steepness provide molecular routes by which quantitative dosage ...
Reiner A. Veitia, James A. Birchler
wiley +1 more source
Nature Communications, 2016 Werner syndrome is a progeroid disease characterised by genetic instability due to mutations to the WRN helicase/exonuclease. Here the authors define a novel Ku binding motif (KBM) and show that two such motifs facilitate the involvement of WRN in DNA ...
Gabrielle J. Grundy +7 more
doaj +1 more source
Deficiency of Werner RecQ-type DNA helicase causes premature malnutrition in zebrafish
iScienceSummary: Werner syndrome is a genetic progeria characterized by premature aging symptoms, but its early-onset pathology remains unclear. We generated wrn truncation mutant (wrn-/-) zebrafish using CRISPR/Cas9 and identified two premature mortality phases:
Kota Ujibe +9 more
doaj +1 more source
Herlyn Werner Wunderlich syndrome. Case report
Taiwanese Journal of Obstetrics & GynecologyObjective: Describe a clinical case of a patient with Herlyn Werner Wunderlich Syndrome in whom an accurate diagnosis was not made during menarche due to failures in her care and poor diagnostic suspicion.
Daniel Alberto Reyes-Martinez +5 more
doaj +1 more source
The epidemiology of premature aging and associated comorbidities
Clinical Interventions in Aging, 2013 Fabio Coppedè Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy Abstract: Hutchinson–Gilford Progeria Syndrome and Werner syndrome, also known as childhood- and adulthood ...
Coppedè F
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Breast cancer in a Hispanic patient with Werner syndrome. [PDF]
J Radiol Case Rep, 2023 Santos MM +4 more
europepmc +1 more source
Model of human aging: Recent findings on Werner’s and Hutchinson-Gilford progeria syndromes
Clinical Interventions in Aging, 2008 Shian-ling Ding1, Chen-Yang Shen2,3,41Department of Nursing, Kang-Ning Junior College of Medical Care and Management, Taipei, Taiwan; 2Institute of Biomedical Sciences, and 3Life Science Library, Academia Sinica, Taipei, Taiwan; 4Graduate Institute of ...
Shian-ling Ding, Chen-Yang Shen
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