Correction: Hold five lines strategy to manage two key points to prevent hospital-acquired infection through ultrasound visualization technology. [PDF]
Front Med (Lausanne)Wei Y, Su J, Tie X, Yin W.
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UNUSUAL COLD WAVE OVER NORTH WEST INDIA FROM 13 TO 23 APRIL 1955
, 1956 S. KUMAR, G. S. BHULLAR
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Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition
Advanced Science, EarlyView.Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han +9 more
wiley +1 more source
Genetic Diversity of <i>Plasmodium falciparum</i> Merozoite Surface Protein 1 and 2 Genes and Their Allele Association With Malaria Severity, Seasons, and Sex in Bamenda, North West Cameroon. [PDF]
Can J Infect Dis Med MicrobiolAchungu CR +5 more
europepmc +1 more source
Advanced Science, EarlyView.This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong +15 more
wiley +1 more source
Time to recovery and predictors among under five children with severe pneumonia admitted to public hospitals in West Gojjam zone Northwest Ethiopia. [PDF]
Sci RepBeza G +5 more
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Advanced Science, EarlyView.This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao +13 more
wiley +1 more source
Quantifying the experiences of Black and Dual Heritage young people in a forensic child and adolescent mental health service. [PDF]
BJPsych BullSandiford MA +3 more
europepmc +1 more source
Hungry for Knowledge: Octopamine Signaling Regulates Hunger‐Enhanced Olfactory Learning
Advanced Science, EarlyView.Researchers demonstrate that hunger state facilitates both aversive and appetitive olfactory learning. Two distinct octopamine signaling pathways are involved in aversive or appetitive memory formation in the hunger state. And, hunger state also facilitates the formation of both types of memories via an evolutionarily conserved norepinephrine (the ...
Huijuan Zhao +14 more
wiley +1 more source