Results 41 to 50 of about 7,035,864 (312)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Semantic Struggles in the Face of Crisis: ‘The West’ as Contested Key Concept in West German Parliamentary Debate (1973/74)

open access: yesRedescriptions, 2021
This article suggests to read West German parliamentary debate on the first oil crisis as a semantic struggle on the concept of the West. Drawing on latest research, the West is considered to be a narrated concept with its meaning being negotiated upon ...
Ann-Judith Rabenschlag
doaj   +1 more source

Reconsidering Legalism [PDF]

open access: yes, 2003
This essay is in the spirit of a friendly amendment. I have found Shklar\u27s central arguments to be more compelling every time I have reread this book over the last twenty years.
West, Robin
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

The Risk of Eroding the Foundations of Human Rights

open access: yesMusica Docta, 2021
This contribution starts from the historical process that led to the UN Universal Declaration of Human Rights (1948, based on that of 1789), followed by increasingly specific ’Declarations’. Over the years, with the global expansion of the UN, the rights
Raffale Romanelli
doaj   +1 more source

"Don't Be Scared" Library Horror Stories posters [PDF]

open access: yes, 2017
These posters were created to make students aware of library resources during the month of October's "Library Horror Stories" media ...
West, Samantha
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Chinese Theatre since 1980

open access: yesCritical Stages, 2018
Chinese theatre has gone through a drastic period of free development and exploration since 1980. Many new phenomena and tendencies have occurred during those years. The article is a panoramic summary of this productive and varied trajectory.
Lin Kehuan
doaj  

Contracts Symposium Issue: Featured Speaker: The Right to Contract as a Civil Right [PDF]

open access: yes, 2014
The right to contract, whether originating in the Constitution, common law, or natural law, has been long and widely felt to be in tension with our civil rights, broadly conceived.
West, Robin
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

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