Results 41 to 50 of about 2,737,894 (314)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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The De-westernizing of cinema; re-thinking in thinking, theorizing, and non-western film making methods [PDF]
مطالعات رسانههای نوین, 2018 Many scholars believed that the current cinema studies has reduced to a simplistic cultural critique. But at now we have a great legacy of the works in the cultural and cinematic studies outside of the western main tendency , without have attracted any ...
Seyyed Emad Hosseini +3 more
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
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Critical Stages, 2018 Chinese theatre has gone through a drastic period of free development and exploration since 1980. Many new phenomena and tendencies have occurred during those years. The article is a panoramic summary of this productive and varied trajectory.
Lin Kehuan
doaj
Redescriptions, 2021 This article suggests to read West German parliamentary debate on the first oil crisis as a semantic struggle on the concept of the West. Drawing on latest research, the West is considered to be a narrated concept with its meaning being negotiated upon ...
Ann-Judith Rabenschlag
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
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The Risk of Eroding the Foundations of Human Rights
Musica Docta, 2021 This contribution starts from the historical process that led to the UN Universal Declaration of Human Rights (1948, based on that of 1789), followed by increasingly specific ’Declarations’. Over the years, with the global expansion of the UN, the rights
Raffale Romanelli
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
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Border between West and East of Europe in the mental maps of European university students
Hungarian Geographical BulletinThe paper addresses the issue of dividing Europe into two sub-regions, West and East, which are monitored and defined through the method of cognitive mapping.
Aleš Nováček +2 more
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