Results 51 to 60 of about 2,737,894 (314)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
West-Friese Archeologische Rapporten 44
, 2020 Bewoningssporen langs de Westfriese ...
Bartels, M.H. (Archeologie West-Friesland) +1 more
core +1 more source
Vestnik MGIMO-Universiteta, 2014 The study of Western countries and teaching courses on the related subjects have longstanding and established tradition at MGIMO-University. The basis of this brilliant research and teaching tradition was laid down by such academicians as E.V.
V. O. Pechatnov, E. O. Obichkina
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Mythological Beginning in Nigerian Literature: A Dialogue between Ch. Achebe and Ch. Obioma [PDF]
Ученые записки Института Африки Российской академии наукThe article examines the peculiarities of the perception of the colonial past and the anti-colonial reaction in the novels of two Nigerian writers: Ch. Achebe (Things Fall Apart, 1958) and Ch. Obioma (The Fishermen, 2015). Both writers share an appeal to
CHUVANOVA Olga Igorevna
doaj +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
West-Friese Archeologische Rapporten 57
, 2020 Van 11 tot en met 18 april 2012 (6 dagen) is een archeologische opgraving uitgevoerd op de locatie Bangert 61 in Zwaag, gemeente Hoorn. Het perceel aan de noordzijde van de Bangert was tot de bouw van de boerderij in de 17de eeuw in gebruik als akker en ...
Duijn, D.M. (Archeologie West-Friesland) +1 more
core +1 more source
Russia and the West, the West and Russia
, 2002 Regionalization of Russian Foreign and Security ...
Androsov, Andrei +7 more
openaire +2 more sources
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source