Results 71 to 80 of about 628,056 (305)

Prenatal Etiologies of West Syndrome

Pediatric Neurology Briefs, 1993
The etiology of West syndrome (WS) with special reference to prenatal factors was investigated in 180 patients admitted between 1969 and 1990 to the Department of Child Neurology, Okayama University Medical School, Japan.
J Gordon Millichap
doaj   +1 more source

Evaluation of waist-to-height ratio to predict 5 year cardiometabolic risk in sub-Saharan African adults [PDF]

, 2014
Simple, low-cost central obesity measures may help identify individuals with increased cardiometabolic disease risk, although it is unclear which measures perform best in African adults.
Fourie, C.M.T., Greeff, M., Huisman, H.W., Kruger, H. Salome, Kruger, I.M., Kruger, R., Rennie, Kirsten, Scheepers, J.D.W., Schutte, A.E., Schutte, R., Uys, A.S., Van Rooyen, J.M., Ware, L.J.   +12 more
core   +1 more source

Single‐Nucleus RNA Sequencing Reveals Mid‐Gestational Neurodevelopment Features in the Superior Temporal Plane from Fetuses with Nonsyndromic Cleft Lip and Palate

Advanced Science, EarlyView.
Single‐nucleus RNA sequencing of mid‐gestation brains from fetuses with nonsyndromic cleft lip and palate reveals major disruptions in cell composition, cell‐to‐cell signaling, and gene regulation. The transcription factor MEF2C is identified as a central regulator of these changes and shows that lowering MEF2C impairs synapse formation, linking cleft ...
Liu‐Lin Xiong, Xin‐Wei Huang, Qiu‐Xia Xiao, Ying‐Gang Zheng, Hao‐Yue Qin, Chang‐Le Fang, Li Chen, Ruo‐Lan Du, Qiu‐Lin Wang, Li‐Ren Huangfu, Ye‐Qing Fei, Yang‐Yang Zhao, Chen‐Yang Zhai, Ze‐Mian Chen, Shi‐Kun Yuan, Yu‐Ji Zhou, Xing‐Man He, Ting‐Ting Zhi, Xiao‐He Tian, Ting‐Hua Wang   +19 more
wiley   +1 more source

"The mad", "the bad", "the victim":gendered constructions of women who kill within the criminal justice system [PDF]

, 2013
Women commit significantly fewer murders than men and are perceived to be less violent. This belief about women’s non-violence reflects the discourses surrounding gender, all of which assume that women possess certain inherent essential characteristics ...
Weare, Siobhan
core   +2 more sources

Diagnosis, Prognosis, and Drug Target Discovery for Chronic Widespread Pain: A Large Proteogenomic Study

Advanced Science, EarlyView.
Plasma proteomics is leveraged to decode the biological underpinnings of chronic widespread pain. A nested machine learning framework integrates proteomic signatures, prospective outcomes, and Mendelian randomization to uncover 18 causal proteins.
Li Chen, Eoin Kelleher, Ruogu Meng, Duanke Liu, Yuchen Guo, Yunhe Wang, Yaqing Gao, Zhe Huang, Zhu Liang, Shuai Yuan, Chao Zeng, Jun Ma, Yanhui Dong, Anushka Irani, Guanghua Lei, Junqing Xie, Daniel Prieto‐Alhambra   +16 more
wiley   +1 more source

Prolonged EEG Depression as a Predictor of West Syndrome in Term Infants with HIE

Pediatric Neurology Briefs, 2011
Seventeen term and near-term infants with hypoxic ischemic encephalopathy (HIE) were studied at Okazaki City Hospital and other centers in Japan to clarify the relationship between prolonged depression of the EEG and later development of West syndrome ...
J Gordon Millichap
doaj   +1 more source

A Porcine Monoclonal Antibody Targeting a Conserved GP4 Epitope Protects against In Vivo Infection via the Induction of Broad‐Spectrum PRRSV Neutralization

Advanced Science, EarlyView.
This study developed mAb‐5F2, a monoclonal antibody targeting conserved GP4 residues (Q48/I50), which blocks the GP4‐CD163 interaction, resulting in a 78–85% reduction in viral entry. Porcineized 5F2‐pFc prevented mortality in infected piglets, reduced pulmonary viral loads, and minimized lesions. This broad‐spectrum antibody platform overcomes vaccine
Xu Chen, Jiakai Zhao, Pinpin Ji, Xiaoxuan Li, Hui Niu, Dian Jiao, Lu Zhang, Qianyi Zhu, Xinyu Liu, Julian A. Hiscox, James P. Stewart, Yani Sun, Qin Zhao   +12 more
wiley   +1 more source

Prediction and prevention of the next pandemic zoonosis. [PDF]

, 2012
Most pandemics--eg, HIV/AIDS, severe acute respiratory syndrome, pandemic influenza--originate in animals, are caused by viruses, and are driven to emerge by ecological, behavioural, or socioeconomic changes.
Carroll, Dennis, Daszak, Peter, Karesh, William B, Lipkin, W Ian, Mazet, Jonna AK, Morse, Stephen S, Parrish, Colin R, Woolhouse, Mark, Zambrana-Torrelio, Carlos   +8 more
core   +1 more source

Refractory Status Epilepticus and Therapeutic Uncertainties: a Comprehensive Review on Targeting Neuroinflammation and Rationale for Developing a Platform Trial

Advanced Science, EarlyView.
Refractory status epilepticus (RSE) is a life‐threatening neurological emergency with high rates of death and long‐term disability, but treatments for it are often based on limited evidence. RSE is now understood to involve neuroinflammation, which has led to the exploration of anti‐inflammatory and immunomodulatory agents like Tocilizumab. Traditional
Shanika Samarasekera, Suneesh Thilak, Asha Patel, Prashant Nasa, Zubair Ahmed, Lorraine Jacques, William J. Scotton, Cyril Chacko, Randeep Mullhi, Ruoling Chen, Vikram Patil, Suresh Renukappa, Tonny Veenith   +12 more
wiley   +1 more source

Developmental Trajectories of Hand Movements in Typical Infants and Those at Risk of Developmental Disorders: An Observational Study of Kinematics during the First Year of Life

Frontiers in Psychology, 2018
HighlightsThe kinematics of hand movements (spatial use, curvature, acceleration, and velocity) of infants with their mothers in an interactive setting are significantly associated with age in cohorts of typical and at-risk infantsdiffer significantly at
Lisa Ouss, Lisa Ouss, Marie-Thérèse Le Normand, Kevin Bailly, Marluce Leitgel Gille, Christelle Gosme, Roberta Simas, Julia Wenke, Xavier Jeudon, Stéphanie Thepot, Telma Da Silva, Xavier Clady, Edith Thoueille, Mohammad Afshar, Bernard Golse, Mariana Guergova-Kuras   +15 more
doaj   +1 more source