Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Carbon sequestration in Danish forests. COST E21 Workshop. Contribution of forests and forestry to mitigate greenhouse effects. Joensuu (Finland). 28-30 Sep 2000. [PDF]
Biotechnologie, Agronomie, Société et Environnement, 2000 The Danish national reports on land-use change and forestry has so far only considered C sequestration in existing forests and in afforestation areas on former arable land. The standing stock of wood in existing forests was 55.2 millions cubic m in 1990,
Vesterdal L.
doaj
Beginings of Christian Education in Western Europe
Folia Historica Cracoviensia, 2002 The article recounts the dawn of Christian education in Western Europe.
Mieczysław Markowski
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Western Winds, November 3, 1999
, 2016 Recorded during a live performance at Dalton Center Recital Hall, Western Michigan University, Kalamazoo, Michigan, November 3, 1999, 8:00 p.m., the 111th concert of the School of Music's 1999-2000 season.1st work transcribed from Rossini's 4th sonata ...
Western Winds
core +1 more source
National forest inventory of Finland and its role estimating the carbon balance forests. COST E21 Workshop. Contribution of forests and forestry to mitigate greenhouse effects. Joensuu (Finland). 28-30 Sep 2000 [PDF]
Biotechnologie, Agronomie, Société et Environnement, 2000 The paper presents the total stem volume increment and total drain, as well as the corresponding carbon contents, of the trees of Finnish forests. The carbon contents are converted to carbon dioxide equivalents.
Tomppo E.
doaj
British direct investment in Western Europe
PSL Quarterly Review, 2014 The paper has two main objects. The first, which is essentially descriptive, is to provide an account of British direct investment in Western Europe in relation to British direct investment as a whole. In attempting this the authors make uses not only of
J.H. DUNNING, D. ROWAN
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Calculation on the impacts of forestation, afforestation and reforestation on the C-sequestration potential in Belgian forests ecosystems. COST E21 Workshop. Contribution of forests and forestry to mitigate greenhouse effects. Joensuu (Finland). 28-30 Sep 2000 [PDF]
Biotechnologie, Agronomie, Société et Environnement, 2000 The Belgian climate policy is formulated at the federal level, requiring cooperation between regional and federal administrations. Around a fifth of the total area of Belgium is covered by forests.
Perrin D., Laitat E., Temmerman M.
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source