Results 41 to 50 of about 4,267,500 (287)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

The Swiss carbon balance: methods, state of reporting and research perspectives. COST E21 Workshop. Contribution of forests and forestry to mitigate greenhouse effects. Joensuu (Finland). 28-30 Sep 2000. [PDF]

open access: yesBiotechnologie, Agronomie, Société et Environnement, 2000
For the 1990-1998 period, Switzerland reported an annual sink strength of Swiss forests of 4500-6000 Gg CO2. In its latest submission in 2000, newly available national forest inventory (NFI) data were used to refine earlier estimates.
Bugmann H.
doaj  

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Elaboration d' une methode quantitative et globale d' evaluation de l' aptitude des terres a l' agriculture: application a la Region wallonne (Belgique) [PDF]

open access: yesBiotechnologie, Agronomie, Société et Environnement, 2000
Setting up a quantitative method for a global evaluation of farmland: application to the Walloon Region (Belgium). To counteract the wasteful use of good quality farmlands by other land uses, we have developed a quantitative method for land evaluation ...
Morelle D., Lejeune P.
doaj  

The Future of Christianity in Western and Northern Europe

open access: yes
This article is the concluding essay of the Western and Northern Europe volume of Edinburgh University Press's series on Global ...
Svenungsson, Jayne   +2 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Western String Chamber Orchestra, March 29, 1993

open access: yes, 2016
Recorded during a live performance at Dalton Center Recital Hall, Western Michigan University, Kalamazoo, Michigan, March 29, 1993, 8:00 p.m., the 419th concert of the School of Music’s 1992-1993 season.Western String Chamber Orchestra, Bruce Uchimura ...
Western String Chamber Orchestra
core   +1 more source

Carbon stocks and sinks in forestry for the unitéd Kingdom greenhouse gas inventory. COST E21 Workshop. Contribution of forests and forestry to mitigate greenhouse effects. Joensuu (Finland). 28-30 Sep 2000 [PDF]

open access: yesBiotechnologie, Agronomie, Société et Environnement, 2000
Afforestation in the UK has been significant and continuing since 1920 (up to 30,000 ha per year). Planting data is used to drive a dynamic process-based carbon accounting model (C-Flow) to estimate removals of atmospheric CO2 to these forests.
Milne R., Hargreaves K., Murray M.
doaj  

Coalition Governance Patterns across Western Europe

open access: yes, 2021
We here summarize and compares the empirical results found by our country authors, focusing on the coalition life cycle in 17 countries. The chapter starts with a description of the changes that have occurred during the past decades in the party systems ...
Bergman, Torbjörn,   +5 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

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