Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
National forest inventory of Finland and its role estimating the carbon balance forests. COST E21 Workshop. Contribution of forests and forestry to mitigate greenhouse effects. Joensuu (Finland). 28-30 Sep 2000 [PDF]
Biotechnologie, Agronomie, Société et Environnement, 2000 The paper presents the total stem volume increment and total drain, as well as the corresponding carbon contents, of the trees of Finnish forests. The carbon contents are converted to carbon dioxide equivalents.
Tomppo E.
doaj
British direct investment in Western Europe
PSL Quarterly Review, 2014 The paper has two main objects. The first, which is essentially descriptive, is to provide an account of British direct investment in Western Europe in relation to British direct investment as a whole. In attempting this the authors make uses not only of
J.H. DUNNING, D. ROWAN
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Calculation on the impacts of forestation, afforestation and reforestation on the C-sequestration potential in Belgian forests ecosystems. COST E21 Workshop. Contribution of forests and forestry to mitigate greenhouse effects. Joensuu (Finland). 28-30 Sep 2000 [PDF]
Biotechnologie, Agronomie, Société et Environnement, 2000 The Belgian climate policy is formulated at the federal level, requiring cooperation between regional and federal administrations. Around a fifth of the total area of Belgium is covered by forests.
Perrin D., Laitat E., Temmerman M.
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
The Swiss carbon balance: methods, state of reporting and research perspectives. COST E21 Workshop. Contribution of forests and forestry to mitigate greenhouse effects. Joensuu (Finland). 28-30 Sep 2000. [PDF]
Biotechnologie, Agronomie, Société et Environnement, 2000 For the 1990-1998 period, Switzerland reported an annual sink strength of Swiss forests of 4500-6000 Gg CO2. In its latest submission in 2000, newly available national forest inventory (NFI) data were used to refine earlier estimates.
Bugmann H.
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Elaboration d' une methode quantitative et globale d' evaluation de l' aptitude des terres a l' agriculture: application a la Region wallonne (Belgique) [PDF]
Biotechnologie, Agronomie, Société et Environnement, 2000 Setting up a quantitative method for a global evaluation of farmland: application to the Walloon Region (Belgium). To counteract the wasteful use of good quality farmlands by other land uses, we have developed a quantitative method for land evaluation ...
Morelle D., Lejeune P.
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source