Results 41 to 50 of about 247,427 (257)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Single strand conformation polymorphism (SSCP) detection in six genes in Portuguese indigenous sheep breed [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2001
Evaluation of the genetic diversity for six genes in forty animals of the Portuguese indigenous sheep breed (Ovis aries) ""Churra da Terra Quente"" was done.
Guedes-Pinto H., Bastos E., Cravador A., Azevedo J.   +3 more
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Mise au point d' un modele cartographique pour la description des stations forestieres en Ardenne belge [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2002
Development of a cartographic mdel for the forest site types delineation in the Belgian Ardenne. The paper presents an original method dealing with the forest site types delineation. The suggested method consists in integrating a typological key in a GIS
Lejeune P., Claessens H., Cuvelier M., Dierstein A., Rondeux J.   +4 more
doaj  

Company value analysis: Empirical evidence from Western Europe [PDF]

Anali Ekonomskog fakulteta u Subotici
The assessment of the future sustainability of the company is based on the analysis of its value. In order to find the best way to maximize value and improve corporate performance, this paper aims to research factors that determine the value of Western ...
Vuković Bojana, Peštović Kristina, Saković Dušan, Ilić Teodora   +3 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Extreme summer temperatures in Western Europe [PDF]

Advances in Science and Research, 2012
We discuss the evolution of summer temperature extremes over Western Europe during 1961–2004 in the context of current climate warming. Using a parametric approach, we investigate the role of properties and changes in probability density functions ...
C. Simolo, M. Brunetti, M. Maugeri, T. Nanni   +3 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Bałkańskie kompleksy „gorszej Europy” w prozie Ermisa Lafazanovskiego

Slavia Meridionalis, 2015
Balkan complexes of “worse Europe” in works of Ermis Lafazanovski Over the centuries, the European continent was divided into different spaces according to different axes: both geopolitical and economic history of East and West and the historical and ...
Lilla Moroz-Grzelak
doaj   +1 more source