Results 41 to 50 of about 641,559 (279)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Swiss carbon balance: methods, state of reporting and research perspectives. COST E21 Workshop. Contribution of forests and forestry to mitigate greenhouse effects. Joensuu (Finland). 28-30 Sep 2000. [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2000
For the 1990-1998 period, Switzerland reported an annual sink strength of Swiss forests of 4500-6000 Gg CO2. In its latest submission in 2000, newly available national forest inventory (NFI) data were used to refine earlier estimates.
Bugmann H.
doaj  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Elaboration d' une methode quantitative et globale d' evaluation de l' aptitude des terres a l' agriculture: application a la Region wallonne (Belgique) [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2000
Setting up a quantitative method for a global evaluation of farmland: application to the Walloon Region (Belgium). To counteract the wasteful use of good quality farmlands by other land uses, we have developed a quantitative method for land evaluation ...
Morelle D., Lejeune P.
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Carbon stocks and sinks in forestry for the unitéd Kingdom greenhouse gas inventory. COST E21 Workshop. Contribution of forests and forestry to mitigate greenhouse effects. Joensuu (Finland). 28-30 Sep 2000 [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2000
Afforestation in the UK has been significant and continuing since 1920 (up to 30,000 ha per year). Planting data is used to drive a dynamic process-based carbon accounting model (C-Flow) to estimate removals of atmospheric CO2 to these forests.
Milne R., Hargreaves K., Murray M.
doaj  

Time for change in Portuguese science [PDF]

, 2014
There is an almost perfect positive relationship between scientific output and gross domestic product (GDP) in Western Europe (Fig. 1).
Canario, Adelino V. M.
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Single strand conformation polymorphism (SSCP) detection in six genes in Portuguese indigenous sheep breed [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2001
Evaluation of the genetic diversity for six genes in forty animals of the Portuguese indigenous sheep breed (Ovis aries) ""Churra da Terra Quente"" was done.
Guedes-Pinto H., Bastos E., Cravador A., Azevedo J.   +3 more
doaj  

Extreme summer temperatures in Western Europe [PDF]

Advances in Science and Research, 2012
We discuss the evolution of summer temperature extremes over Western Europe during 1961–2004 in the context of current climate warming. Using a parametric approach, we investigate the role of properties and changes in probability density functions ...
C. Simolo, M. Brunetti, M. Maugeri, T. Nanni   +3 more
doaj   +1 more source