Results 71 to 80 of about 9,392,646 (337)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
State Highlights 4/11/1945 [PDF]
, 1945 This is the student newspaper from Western State High School, the high school that was on the campus of Western Michigan University, then called State Highlights, in ...
, Western State High School
core +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
State Highlights 12/17/1952 [PDF]
, 1952 This is the student newspaper from Western State High School, the high school that was on the campus of Western Michigan University, then called State Highlights, in 1952.
, Western State High School
core +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
La persistance du western : Yellowstone, la Nouvelle télévision et l’histoire américaine
Cahiers d’histoireThis essay will explore the ways in which the western has found new life in new television, especially in the recent neo-western Yellowstone. The paper pursues the significance of the western for both the medium of new television and for the construction
Martin Shuster
doaj +1 more source
State Highlights 3/5/1952 [PDF]
, 1952 This is the student newspaper from Western State High School, the high school that was on the campus of Western Michigan University, then called State Highlights, in ...
, Western State High School
core +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Italies, 2001 Si Sergio Leone n’est pas l’inventeur du western italien, il est en revanche le chef de file d’une nouvelle école de réalisateurs de westerns, longtemps taxée de médiocrité parasitaire et frauduleuse en regard de la tradition hollywoodienne, puis ...
José Pagliardini
doaj +1 more source