Results 91 to 100 of about 3,769,094 (311)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Western Brass Quintet, October 29, 1980
, 2019 Recorded during a live performance at Kanley Chapel, Western Michigan University, Kalamazoo, Michigan on October 29, 1980, 4:00 p.m., program no. 46 of the School of Music's 1980-1981 season.Western Brass Quintet (Donald Bullock and Stephen Jones ...
Western Brass Quintet
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La posguerra española en clave de western rural
Trasvases Entre la Literatura y el CineEl cine español contemporáneo sobre la memoria histórica ha renovado sus modelos con técnicas y motivos del western. Dos casos notables son las adaptaciones de Sordo (Alfonso Cortés-Cavanillas, 2018) e Intemperie (Benito Zambrano, 2019).
Álvaro López Fernández +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Western String Chamber Orchestra, November 11, 1992
, 2016 Recorded at Dalton Center Recital Hall, November 11, 1992.Western String Chamber Orchestra, Bruce Uchimura, conductor ; Tanya Treat, cello (in the 2nd work) ; Kristin van Ausdal, violin (in the 4th work) ; Jonathon Ellis, viola (in the 4th work).Sinfonia
Western String Chamber Orchestra
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A Book on the Making of Lonesome Dove, by John Spong
Alphaville: Journal of Film and Screen Media, 2013 The Western is surely one of the most enduring and characteristically American genres. Its exponents in cinema have included such distinguished filmmakers as John Ford, Howard Hawks, Budd Boetticher, Sam Peckinpah and Clint Eastwood.
Matthew Carter
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Western Brass Quintet, October 28, 1977
, 2018 Recorded during a live performance at Oakland Recital Hall, Western Michigan University, Kalamazoo, October 28, 1977, program no. 31 of the Department of Music's 1977-1978 season.Western Brass Quintet (Donald Bullock, Stephen Jones, trumpets ; Connie ...
Western Brass Quintet
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Western String Quartet, October 13, 1978
, 2018 Recorded during a live performance at Oakland Recital Hall, Western Michigan University, October 13, 1978, program no. 25 of the Department of Music's 1978-1979 season.Western String Quartet (Gerald Fischbach and Barry Ross, violins; Joseph Work, viola ...
Western String Quartet
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