Results 211 to 220 of about 2,391,044 (330)

Aboriginal burning promotes fine-scale pyrodiversity and native predators in Australia's Western Desert

, 2018
R. Bird, Douglas W. Bird, L. E. Fernandez, N. Taylor, W. Taylor, D. Nimmo   +5 more
semanticscholar   +1 more source

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, EarlyView.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source

Desert Sand and Dust Storms and Desert Dust Episodes: Major Patterns to be Accounted for to Protect the Health of Exposed Population: A Review. [PDF]

ACS EST Air
Querol X, Fussell JC, Saliba NA, Al-Hemoud A, Nadeau KC, Tobías A, Hashizume M, Malkawi M, Gumy SP, Shairsingh KK, Mudu P, Hopke PK.   +11 more
europepmc   +1 more source

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

Drivers of Shrub Community Assembly in Semi-Arid Ecosystems: Integrated Evidence from Environmental Stress on the Western Loess Plateau. [PDF]

Biology (Basel)
Li M, Dang H, Du J, Liu D, Yu T, Xu J, Han B, Ding P, Hu D.   +8 more
europepmc   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Quantitative analysis of sediment source contributions to the different deposits in the Taklamakan Desert, western China, determined using discriminant function analysis. [PDF]

Sci Rep
Zhou Y, Chen B, Huang W.
europepmc   +1 more source

Entobia ichnofacies from the Middle Miocene carbonate succession of the northern Western Desert of Egypt

, 2018
M. El-Hedeny, A. El‐Sabbagh
semanticscholar   +1 more source

Inverted stream channels in the Western Desert of Egypt: Synergistic remote, field observations and laboratory analysis on Earth with applications to Mars

Icarus (New York, N.Y. 1962), 2018
A. Zaki, C. Pain, K. Edgett, R. Giegengack   +3 more
semanticscholar   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source