Results 41 to 50 of about 24,556 (268)

Some normal hematological values of Arabian camels reared in western desert of Al-Najaf governorate/ Iraq [PDF]

Mirror of Research in Veterinary Sciences and Animals, 2015
This study was designed to study some normal hematological values of Arabian camels reared in western desert of Al-Najaf governorate/ Iraq. Blood samples was collected with anticoagulant tube from 78 free breeding Arabian camels in western desert of Al ...
Hayder M. Al-Rammahi, Hamed A. Al-Jebory, Huda Abed Al-Sattar   +2 more
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Evaluation of the nature, origin and potentiality of the subsurface Middle Jurassic and Lower Cretaceous source rocks in Melleiha G-1x well, North Western Desert, Egypt

Egyptian Journal of Petroleum, 2015
The present work aims to evaluate the nature and origin of the source rock potentiality of subsurface Middle Jurassic and Lower Cretaceous source rocks in Melleiha G-1x well.
Mohamed M. El Nady
doaj   +1 more source

Tectonostratigraphic Evolution of the Western Desert of Iraq

IOP Conference Series: Earth and Environmental Science, 2022
Abstract The study area is in the northern part of the Western Desert of Iraq. From the conclusion of Paleozoic and Mesozoic basins and their distribution according to the available geological (outcrops and boreholes) and geophysical data (seismic, gravity and magnetic interpretations controlled by geological data), it is found that ...
Abdul Hameed A. Alhadiathy, Isam Najar
openaire   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Scientific value and utility of geo(morpho)sites, with a case of the El-Medallat hills in Egypt

Discover Geoscience
Geological and geomorphological heritage (geoheritage) has many aspects, some of which are yet to be fully understood. Particularly, a scientific value of geo(morpho)sites is defined differently and established with not fully satisfying approaches.
Dmitry A. Ruban, Emad S. Sallam
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Impact of solar and wind development on conservation values in the Mojave Desert.

PLoS ONE, 2018
In 2010, The Nature Conservancy completed the Mojave Desert Ecoregional Assessment, which characterizes conservation values across nearly 130,000 km2 of the desert Southwest.
Sophie S Parker, Brian S Cohen, James Moore   +2 more
doaj   +1 more source