Results 61 to 70 of about 135,370 (254)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Western Perceptions of the Soviet Union in 1945

Vestnik MGIMO-Universiteta, 2010
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D. Roberts
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

European Defence Community: origins of integration in the defence sphere

Проблеми Законності, 2017
There is a tendency among non-historians to force «practioners» of the discipline to justify why the study of a particular episode of the past is so important and to articulate the lessons to be learned from the experience.
Іван Васильович Яковюк, Роман Русланович Орловський   +1 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Neutrophil Extracellular Traps in Cardiovascular Diseases: Pathological Roles and Therapeutic Implications

Biomolecules
Cardiovascular disease (CVD) is currently recognized as one of the leading health threats to humanity. Neutrophils play an important role in innate immune response.
Yan Ma, Jun Zhang, Yaxuan Qi, Yating Lu, Yalan Dong, Desheng Hu   +5 more
doaj   +1 more source

POSTWAR INTERNATIONAL ORGANIZATIONS PREDECESSOR OF THE EUROPEAN UNION [PDF]

Challenges of the Knowledge Society, 2017
The European Union, as its existence that we can meet in the present moment, is not a creation which came out of nothing or arising of the history’s hazard, but is rather an evolutionary process that began after the end of the Second World War.
Dragoș-Adrian BANTAȘ, Elvira BELDIMAN
doaj  

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Research status and prospects of molecular pathological mechanisms and novel therapeutic targets of osteosarcoma: a systematic review

Frontiers in Oncology
BackgroundThe treatment of osteosarcoma, a highly aggressive primary malignant bone tumour, has long faced limitations due to chemotherapy resistance, tumour het-erogeneity, and an immunosuppressive microenvironment.MethodsThis review synthesizes recent ...
Huan Jin, Huan Jin, Cai Huang, Ying Dong, Qi Xiong, Di Wang, Di Wang, Ziyi He, Ziyi He, Yu Shang, Lin Shen, Chen Ma, Zixian Wang, Siwei Shi, LingFeng Zeng, Bo Shuai   +15 more
doaj   +1 more source