Results 231 to 240 of about 24,687 (267)

Twin screw wet granulation: Granule properties

Chemical Engineering Journal, 2010
Abstract Granulation is an important particle size enlargement process, used in many applications. Granulation has, for many years, been a batch process because of a greater knowledge base. However, the technique of using a twin screw granulator has been found to be very effective at granulating and is an attractive proposition for manufacturing ...
Ranjit M. Dhenge, Richard S. Fyles, James J. Cartwright, David G. Doughty, Michael J. Hounslow, Agba D. Salman   +5 more
openaire   +1 more source

Is Silicified Wet-Granulated Microcrystalline Cellulose Better than Original Wet-Granulated Microcrystalline Cellulose?

Pharmaceutical Development and Technology, 1999
The purpose of this study was to investigate the effect of granulating water level on the physical-mechanical properties of microcrystalline cellulose (MCC) and silicified microcrystalline cellulose (SMCC). Granulations containing either MCC or SMCC were manufactured at different water levels using a high-shear mixer and were then tray-dried. The water
Y S, Habib, R, Abramowitz, R L, Jerzewski, N B, Jain, S N, Agharkar   +4 more
openaire   +2 more sources

Continuous Wet Granulation

2020
Wet granulation is a critical unit operation in solid dosage form manufacturing in the pharmaceutical industry. Traditionally, wet granulation has been a batch process. Recently, there has been a move toward more advanced manufacturing approaches such as continuous processing to allow more rigorous process control, consistent quality assurance, and ...
Arwa El Hagrasy, Li Ge Wang, Jim Litster
openaire   +1 more source

Granulation: A Review on Pharmaceutical Wet-Granulation

Drug Development and Industrial Pharmacy, 1987
AbstractRecent developments in pharmaceutical wet granulation techniques are reviewed with the main emphasis on granulation in fluidized beds and high shear mixers. The following items are dealt with: Fundamentals of granule growth, granulation methods and equipments, granulation variables, scaling-up and end-point control.
H. Gjelstrup Kristensen, T. Schaefer
openaire   +1 more source

Carboxymethylstarches in Wet Granulation

Drug Development and Industrial Pharmacy, 1983
AbstractCommercialized carboxymethystarches (CMS) are both carboxyme-thylated and cross linked potato starch.The influence of carboxymethylation and cross linkage on the disintegrating properties of starch are studied.Tablets are made with acetaminophen as drug, Emcompress as diluant, Magnesium stearat as lubricant, and potato starch or its derivatives
Professor A.M. Guyot-Hermann, Professor J.C. Guyot, Doctor J. Ringard   +2 more
openaire   +1 more source

Tray Drying of Pharmaceutical Wet Granulations

Journal of Pharmaceutical Sciences, 1982
It is shown that in tray drying wet granulated materials, the expected log-linear plots give slopes that are inversely proportional to the bed depth, rather than to the depth squared. A model is proposed for this giving diffusion coefficients of the order of magnitude expected fro liquid-water diffusion.
J T, Carstensen, M A, Zoglio
openaire   +2 more sources

Twin screw wet granulation: Binder delivery

International Journal of Pharmaceutics, 2015
The effects of three ways of binder delivery into the twin screw granulator (TSG) on the residence time, torque, properties of granules (size, shape, strength) and binder distribution were studied. The binder distribution was visualised through the transparent barrel using high speed imaging as well as quantified using offline technique.
Mohammed F, Saleh, Ranjit M, Dhenge, James J, Cartwright, Michael J, Hounslow, Agba D, Salman   +4 more
openaire   +2 more sources

Fluidization of wet granulates under shear

Physical Review E, 2010
Small amounts of a wetting liquid render sand a stiff and moldable material. The cohesive forces between the sand grains are caused by capillary bridges at the points of contact. Due to the finite strength of these bridges wet sand undergoes a transition from an arrested (i.e., solidified) to a fluidized state under an externally applied shear force ...
Ebrahimnazhad Rahbari, H., Vollmer, J., Herminghaus, S., Brinkmann, M.   +3 more
openaire   +3 more sources

Prospective Validation of High-Shear Wet Granulation Process by Wet Granule Sieving Method. II. Utility of Wet Granule Sieving Method

Drug Development and Industrial Pharmacy, 1997
AbstractThe general utility of a method for determination of high-shear wet granulation end point by monitoring the wet granule particle size distribution was evaluated. Wet granulation was conducted in a 25-liter high-shear mixer using four model drugs with different solubilities and particle sizes (ethenzamide, unmilled and milled acetaminophen, and ...
Hisatoshi Emori, Yoko Sakuraba, Koji Takahashi, Toshiaki Nishihata, Tadanori Mayumi   +4 more
openaire   +1 more source

Roles of Granule Size in Over-Granulation During High Shear Wet Granulation

Journal of Pharmaceutical Sciences, 2010
A mechanistic understanding of the over-granulation problem during high shear wet granulation (HSWG) process can guide efficient development of robust formulation and manufacturing process. Using microcrystalline cellulose (MCC) as a model compound, we demonstrate that size enlargement is an important mechanism for over-granulation in HSWG.
Limin, Shi, Yushi, Feng, Changquan Calvin, Sun   +2 more
openaire   +2 more sources