Results 241 to 250 of about 24,687 (267)

Coalescence of deformable granules in wet granulation processes

AIChE Journal, 2000
AbstractIn this work, the coalescence of deformable granules in wet granulation processes is modelled. The model accounts for both the mechanical properties of the granules and the effect of the liquid layer at the granule surface. It is an extension to the model of Ennis et al.
Liu, L. X., Litster, J. D., Iveson, S. M., Ennis, B. J.   +3 more
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Computer simulation of wet granulation

Powder Technology, 2000
Abstract Agglomeration of fine particles in wet granulation is achieved by introducing a binder fluid onto a shearing mass of powder. Owing to the viscosity and the surface tension of the fluid, powder particles are bound together to form larger aggregates.
Ilkay Talu, Gabriel I. Tardos, M.Irfan Khan   +2 more
openaire   +1 more source

Modelling nucleation in wet granulation

Chemical Engineering Science, 2005
Nucleation is the first stage in any granulation process where binder liquid first comes into contact with the powder. This paper investigates the nucleation process where binder liquid is added to a fine powder with a spray nozzle. The dimensionless spray flux approach of Hapgood et al. (Powder Technol.
Wildeboer, W. J., Litster, J. D., Cameron, I. T.   +2 more
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Migration of Potent Drugs in Wet Granulations

Journal of Pharmaceutical Sciences, 1972
Sodium warfarin tablets prepared by a wet granulation method were shown to be unsatisfactory as to content uniformity due to the migration of the drug substance during the drying period. By using a TLC method, additives were selected which inhibited the migration of the drug substance.
I A, Chaudry, R E, King
openaire   +2 more sources

Process optimization for continuous extrusion wet granulation

Pharmaceutical Development and Technology, 2010
Three granulating binders in high drug-load acetaminophen blends were evaluated using high shear granulation and extrusion granulation. A polymethacrylate binder enhanced tablet tensile strength with rapid disintegration in simulated gastric fluid, whereas polyvinylpyrrolidone and hydroxypropyl cellulose binders produced less desirable tablets.
Li, Tan, Anthony J, Carella, Yukun, Ren, Julian B, Lo   +3 more
openaire   +2 more sources

Prospective Validation of High-Shear Wet Granulation Process by Wet Granule Sieving Method. I. Selection and Characterization of Sieving Parameters for Wet Granules

Drug Development and Industrial Pharmacy, 1997
AbstractTo characterize the progression of high-shear wet granulation for various drugs and formulations based on the particle size distribution of wet granules during granulation, a general sieving method for wet granules was investigated. Wet granulation was conducted in a 25-liter high-shear mixer using four model drugs with different solubilities ...
Hisatoshi Emori, Teruhisa Yoshizawa, Toshiaki Nishihata, Tadanori Mayumi   +3 more
openaire   +1 more source

Compressibility and compactibility of granules produced by wet and dry granulation

International Journal of Pharmaceutics, 2008
The bulk properties, compactibility and compressibility of granules produced by wet and dry granulation were compared applying a rotary tablet press, three different morphological forms of calcium carbonate and two particle sizes of sorbitol. Granules from both granulation methods possessed acceptable flow properties; however, the ground (Mikhart) and ...
Bacher, Charlotte, Olsen, P.M., Berthelsen, P., Møller-Sonnergaard, Jørn   +3 more
openaire   +3 more sources

WET GRANULATION TECHNOLOGY IN INDUSTRIAL PHARMACY

"Medical & pharmaceutical journal "Pulse", 2022
Abstract. This review discusses wet granulation technology, a process that helps particles of different materials bind to each other, thereby reducing the possibility of separation of materials in subsequent processing steps during their processing and increasing the likelihood of proper dosage uniformity in the dosage form.
openaire   +1 more source

Twin screw wet granulation: Effects of properties of granulation liquid

Powder Technology, 2012
Abstract The effect of the properties of the granulation liquid, i.e. viscosity (amount of binder) and surface tension on residence time, torque and granule properties such as size, shape, structure, strength and flowability was studied in a co-rotating twin screw granulator.
Ranjit M. Dhenge, James J. Cartwright, Michael J. Hounslow, Agba D. Salman   +3 more
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STEAM GRANULATION VERSUS WET GRANULATION: IMPACT ON GRANULE AND TABLETS PROPERTIES

2023
Steam granulation (SG) involves the use of steam as the granulating medium instead of traditional liquid water [1]. Steam provides a higher diffusion rate into the powder bed and a more favourable thermal balance during the drying step. Due to the ability of the steam to diffuse, a reduction of up to 50% of the amount of water necessary for granulation
Erica Franceschinis, Elena Fontanel, Giulia De Santi, Nicola Realdon, Greta C. Magnano, Dario Voinovich   +5 more
openaire   +2 more sources