Results 281 to 290 of about 26,103 (323)

Is Silicified Wet-Granulated Microcrystalline Cellulose Better than Original Wet-Granulated Microcrystalline Cellulose?

Pharmaceutical Development and Technology, 1999
The purpose of this study was to investigate the effect of granulating water level on the physical-mechanical properties of microcrystalline cellulose (MCC) and silicified microcrystalline cellulose (SMCC). Granulations containing either MCC or SMCC were manufactured at different water levels using a high-shear mixer and were then tray-dried. The water
Y S, Habib, R, Abramowitz, R L, Jerzewski, N B, Jain, S N, Agharkar   +4 more
openaire   +2 more sources

Prospective Validation of High-Shear Wet Granulation Process by Wet Granule Sieving Method. I. Selection and Characterization of Sieving Parameters for Wet Granules

Drug Development and Industrial Pharmacy, 1997
AbstractTo characterize the progression of high-shear wet granulation for various drugs and formulations based on the particle size distribution of wet granules during granulation, a general sieving method for wet granules was investigated. Wet granulation was conducted in a 25-liter high-shear mixer using four model drugs with different solubilities ...
Hisatoshi Emori, Teruhisa Yoshizawa, Toshiaki Nishihata, Tadanori Mayumi   +3 more
openaire   +1 more source

Computer simulation of wet granulation

Powder Technology, 2000
Abstract Agglomeration of fine particles in wet granulation is achieved by introducing a binder fluid onto a shearing mass of powder. Owing to the viscosity and the surface tension of the fluid, powder particles are bound together to form larger aggregates.
Ilkay Talu, Gabriel I. Tardos, M.Irfan Khan   +2 more
openaire   +1 more source

Modelling nucleation in wet granulation

Chemical Engineering Science, 2005
Nucleation is the first stage in any granulation process where binder liquid first comes into contact with the powder. This paper investigates the nucleation process where binder liquid is added to a fine powder with a spray nozzle. The dimensionless spray flux approach of Hapgood et al. (Powder Technol.
Wildeboer, W. J., Litster, J. D., Cameron, I. T.   +2 more
openaire   +4 more sources

Twin screw granulation as a simple and efficient tool for continuous wet granulation

International Journal of Pharmaceutics, 2004
The modification of a twin screw extruder for continuous wet granulation was investigated. Modification of the extruder setup as well as the screw design allowed the continuous wet granulation of alpha-lactose monohydrate without the need of a wet sieving step.
E I, Keleb, A, Vermeire, C, Vervaet, J P, Remon   +3 more
openaire   +2 more sources

Visualization of a Pharmaceutical Unit Operation:  Wet Granulation

Analytical Chemistry, 2004
Recent developments in the field of process engineering and manufacturing sciences enable a new level of process understanding. However, extracting this understanding from increasing amounts of information is challenging. The aim of this study was to create a process vector from a model process describing all relevant information and, by that means ...
Jørgensen, Anna Cecilia, Rantanen, Jukka, Luukkonen, Pirjo, Laine, Sampsa, Yliruusi, Jouko   +4 more
openaire   +3 more sources

End-Point Detection in a Wet Granulation Process

Pharmaceutical Development and Technology, 2001
The purpose of the experiments in this paper was to evaluate granulation end-point control by power consumption measurement in a 25-L high shear mixer. The effect of impeller design, impeller speed, liquid addition rate, type of binder, and mixing ratio between lactose and starch on the correlation between power consumption and granule growth was ...
P, Holm, T, Schaefer, C, Larsen
openaire   +2 more sources

STEAM GRANULATION VERSUS WET GRANULATION: IMPACT ON GRANULE AND TABLETS PROPERTIES

2023
Steam granulation (SG) involves the use of steam as the granulating medium instead of traditional liquid water [1]. Steam provides a higher diffusion rate into the powder bed and a more favourable thermal balance during the drying step. Due to the ability of the steam to diffuse, a reduction of up to 50% of the amount of water necessary for granulation
Erica Franceschinis, Elena Fontanel, Giulia De Santi, Nicola Realdon, Greta C. Magnano, Dario Voinovich   +5 more
openaire   +2 more sources

A review of monitoring methods for pharmaceutical wet granulation

International Journal of Pharmaceutics, 2014
High-shear wet granulation is commonly used in the pharmaceutical industry to improve powder properties for downstream processes such as tabletting. Granule growth, however, is difficult to predict because the process is sensitive to raw material properties and operating conditions.
E M, Hansuld, L, Briens
openaire   +2 more sources

Twin screw wet granulation: Binder delivery

International Journal of Pharmaceutics, 2015
The effects of three ways of binder delivery into the twin screw granulator (TSG) on the residence time, torque, properties of granules (size, shape, strength) and binder distribution were studied. The binder distribution was visualised through the transparent barrel using high speed imaging as well as quantified using offline technique.
Mohammed F, Saleh, Ranjit M, Dhenge, James J, Cartwright, Michael J, Hounslow, Agba D, Salman   +4 more
openaire   +2 more sources