Results 91 to 100 of about 162,110 (330)

Investigation of a Carbapenemase-producing Acinetobacter baumannii outbreak using whole genome sequencing versus a standard epidemiologic investigation

Antimicrobial Resistance and Infection Control, 2018
Background The standard epidemiologic investigation of outbreaks typically relies on spatiotemporal data and pulsed-field gel electrophoresis (PFGE), but whole genome sequencing (WGS) is becoming increasingly used.
Chloe Bogaty, Laura Mataseje, Andrew Gray, Brigitte Lefebvre, Simon Lévesque, Michael Mulvey, Yves Longtin   +6 more
doaj   +1 more source

Fluorescence monitoring of capilarry electrophoresis separation in a lab-on-a-chip with monolithically integrated waveguides [PDF]

, 2008
Femtosecond-laser-written optical waveguides were monolithically integrated into a commercial lab-on-a-chip to intersect a microfluidic channel. Laser excitation through these waveguides confines the excitation window to a width of 12 μm, enabling high ...
Besselink, G.A.J., Cerullo, G., Dekker, R., Dongre, C., Hoekstra, H.J.W.M., Martinez-Vazquez, R., Osellame, R., Pollnau, M., Ramponi, R., Vlekkert, H.H. van den, Weeghel, R. van   +10 more
core   +1 more source

Association of Clonal Hematopoiesis with Incident, Late‐Onset, Seropositive Rheumatoid Arthritis

Arthritis &Rheumatology, Accepted Article.
Objectives Clonal hematopoiesis (CH), defined by acquired driver mutations in hematopoietic stem cells, is associated with many inflammatory diseases of aging. We investigated whether CH and its subtypes, clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alteration (mCA), are associated with incident rheumatoid arthritis (RA)
Kun Zhao, Yash Pershad, J. Brett Heimlich, Michelle Ormseth, C. Michael Stein, Brian Sharber, Caitlyn Vlasschaert, Alexander G. Bick, Robert W. Corty   +8 more
wiley   +1 more source

A Validation Approach of an End-to-End Whole Genome Sequencing Workflow for Source Tracking of Listeria monocytogenes and Salmonella enterica

Frontiers in Microbiology, 2018
Whole genome sequencing (WGS), using high throughput sequencing technology, reveals the complete sequence of the bacterial genome in a few days. WGS is increasingly being used for source tracking, pathogen surveillance and outbreak investigation due to ...
Anne-Catherine Portmann, Coralie Fournier, Johan Gimonet, Catherine Ngom-Bru, Caroline Barretto, Leen Baert   +5 more
doaj   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

The invasive GAS puzzle in Italy: genomic insights from a hospital cohort in a fragmented surveillance landscape

Frontiers in Cellular and Infection Microbiology
Streptococcus pyogenes (Group A Streptococcus, GAS) is a re-emerging human pathogen responsible for a wide spectrum of diseases, from mild pharyngitis to life-threatening invasive infections that have risen globally in recent years.
Roberto Rosato, Giulia Santarelli, Barbara Fiori, Francesca Romana Monzo, Francesca Romana Monzo, Giordana Cafaro, Tiziana D’Inzeo, Marilena La Sorda, Roberta Creti, Brunella Posteraro, Brunella Posteraro, Brunella Posteraro, Maurizio Sanguinetti, Maurizio Sanguinetti, Maurizio Sanguinetti, Flavio De Maio, Flavio De Maio   +16 more
doaj   +1 more source

DIHNET – Presentation – 7 WG meeting – Feedback DIHNET WG- 01072019

, 2019
Begoña Sánchez's (TECNALIA) presentation "Feedback from the DIHNET WGs and approach to the breakout 1". 7th Working Group meeting on DIHs. 1st July 2019, Brussels.
openaire   +1 more source

WEHRMACHTGEFÄNGNIS (WG) GLATZ

, 2022
Three separate “fortress prisons” existed in the eighteenth-century fortress in Glatz (map 4e) (today Kłodzko, Poland) in the period before World War II.1 On January 10, 1938, the fortress prison was closed to new arrivals, and, in its place, WG Glatz was established.
openaire   +1 more source

Sequential, chromosome‐specific glutamine synthetase double knockout with Cas‐CLOVER establishes enhanced CHO platforms for cell line development

Biotechnology Progress, EarlyView.
This study established the first creation of a commercially available double GS knockout (DKO) from a single KO in CHO‐K1 cells, called CleanCut GS CHO using Cas‐CLOVER. When combined with the Harbor‐IN transposase system, CleanCut GS CHO cells demonstrated a highly antibody productivity.
Cintia Gomez Limia, Valeriya Steffey, Hsueh Che Cheng, Daniel Machado, Thomas Hart, Mark Cameron McHargue, Corey Brizzee, Jack Crawford   +7 more
wiley   +1 more source

A comprehensive benchmarking of WGS-based structural variant callers [PDF]

, 2020
Varuni Sarwal, Sebastian Niehus, Ram Ayyala, Sei Chang, Angela Lu, Nicholas Darci-Maher, Russell Littman, Karishma Chhugani, Arda Söylev, Zoia Comarova, Emily Wesel, Jacqueline Castellanos, Rahul Chikka, Margaret G. Distler, Eleazar Eskin, Jonathan Flint, Serghei Mangul   +16 more
openalex   +1 more source