Results 141 to 150 of about 90,363 (315)

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

Thirty Years of Maintaining WGS 84 with GPS

Navigation
With the release of a new International Terrestrial Reference Frame (ITRF) in April 2022, the National Geospatial-Intelligence Agency (NGA) began the process of aligning the World Geodetic System 1984 Terrestrial Reference Frame (WGS 84 TRF) to the ...
William Konyk, Alex Smith, Bob Wong, Andrew Tollefson   +3 more
doaj   +1 more source

Resolving a Complex Neonatal Phenotype by Rapid Trio Whole‐Genome Sequencing: A De Novo 11q14.3–q22.3 Deletion and a Splicing‐Altering Synonymous ANK1 Variant

Journal of Clinical Laboratory Analysis, EarlyView.
Clinical utility of trio WGS and time metrics in a neonate with congenital anomalies and hemolytic anemia. ABSTRACT Background Neonates with complex and evolving phenotypes often lack sufficiently specific clinical features to guide targeted genetic testing.
Hyun‐Woo Lee, Ja‐Hyun Jang, Beom Hee Lee, Hee‐Jeong Youk, Eun Sun Kim, Kee Hyun Cho, Yun Sil Chang, Heui Seung Jo, Mi‐Ae Jang   +8 more
wiley   +1 more source

Zinc‐stabilized stannous fluoride modulates the periodontal microbiome, reducing Fusobacteria, key Gram‐negative species, and overall inflammation within an experimental gingivitis clinical trial

Journal of Periodontology, EarlyView.
Abstract Background This study aimed to evaluate the effects of a dentifrice containing stannous fluoride stabilized with zinc phosphate on subgingival microbiome composition and clinical inflammation during experimental gingivitis, compared with a sodium fluoride control. Methods This investigation was conducted as a secondary analysis of a randomized,
Kristopher A. Kerns, Allison A. Naumann, Lay Y. Soon, Erik L. Hendrickson, Abdelahhad Barbour, Dandan Chen, Harsh M. Trivedi, Michael Glogauer, Jeffrey S. McLean   +8 more
wiley   +1 more source

Current Evidence for Circulating Tumor DNA in Sarcoma: Challenges and Opportunities for Clinical Application

Journal of Surgical Oncology, EarlyView.
ABSTRACT Sarcomas represent a diverse group of mesenchymal tumors with high rates of recurrence after resection. While recent technical advances have enabled the detection of rare circulating tumor DNA (ctDNA) in other malignancies, the complexity and heterogeneity of sarcoma genomics have historically limited ctDNA in these cancers.
Kristin E. Goodsell, Jason A. Carter, Hannah R. Abrams, Harveshp Mogal, Elizabeth T. Loggers, Jeremy Sharib   +5 more
wiley   +1 more source

Significant Imbalance Between Human Activities and Ecosystem Services in the Tibet Autonomous Region of China: Evidence From an Improved Coupling Coordination Degree Model

Land Degradation &Development, EarlyView.
ABSTRACT Maintaining balanced interactions between humans and ecosystems in plateau regions is critical to achieving global sustainable development. However, existing methodologies are insufficient to fully elucidate the complex coupling and coordination relationships between human activities and ecosystems, as well as the sustainable development ...
Yaohang Sun, Dongxia Yue, Jianjun Guo, Hanhua Deng, Jiaoyu Zheng, Gang Jin   +5 more
wiley   +1 more source

Zagros Restoration: Smart Choices for Oak Forests

Land Degradation &Development, EarlyView.
ABSTRACT Widespread forest degradation across the northern Zagros region of Iran driven by both human activity and natural processes has created an urgent need for targeted afforestation and forest enrichment strategies. Hence, the aim of this study was identifying the most suitable native tree and shrub species for restoring degraded forest areas in ...
Farzad Yavari, Ahmad Alijanpour, Abbas Banj Shafiei, Hadi Beygi Heidarlou, Alishir Kurban, Anwar Eziz, Hossein Azadi   +6 more
wiley   +1 more source

Assessing Soil Erosion in a Typical Karst Region: A Model Improved by Bedrock Exposure Rate in Guizhou Province

Land Degradation &Development, EarlyView.
ABSTRACT Soil erosion is a major environmental challenge in karst regions of Southwest China, where thin soils and high bedrock exposure accelerate land degradation. This study modified the RUSLE model by incorporating bedrock exposure rate to improve erosion simulation in Guizhou Province from 2000 to 2024.
Ning Niu, Jihui Fan, Yiying Li
wiley   +1 more source

Asymmetric Responses of Ecosystem Health to Urbanization in a Typical Karst City: Spatiotemporal Patterns and Driving Mechanisms in Guilin, China

Land Degradation &Development, EarlyView.
ABSTRACT Urban expansion can substantially reshape ecosystem structure and functioning, especially in ecologically fragile Karst landscapes. Clarifying how ecosystem health (EH) responds to urbanization and identifying the factors that drive spatial variation in EH are important for regional sustainability.
Jinlong Hu, Zhenhong Bin, Yingxue Wang
wiley   +1 more source

Outreach events for WG II, WG WG III and the Synthesis Report

Dissemination events for the Working Group contributions to the IPCC AR6 and the Synthesis Report. (48/2024)
openaire   +1 more source