Results 41 to 50 of about 174,007 (375)

Wg secreted by conventional Golgi transport diffuses and forms Wg gradient whereas Wg tethered to extracellular vesicles do not diffuse

Cell Death & Differentiation, 2020
Wingless (Wg)/Wnt family proteins are essential for animal development and adult homeostasis. Drosophila Wg secreted from the dorsal-ventral (DV) midline in wing discs forms a concentration gradient that is shaped by diffusion rate and stability of Wg.
Jong-Hoon Won, Kyung-Ok Cho
openaire   +3 more sources

The Present and Future of Whole Genome Sequencing (WGS) and Whole Metagenome Sequencing (WMS) for Surveillance of Antimicrobial Resistant Microorganisms and Antimicrobial Resistance Genes across the Food Chain

Genes, 2018
Antimicrobial resistance (AMR) surveillance is a critical step within risk assessment schemes, as it is the basis for informing global strategies, monitoring the effectiveness of public health interventions, and detecting new trends and emerging threats ...
Elena-Alexandra Oniciuc, E. Likotrafiti, Adrián Alvarez-Molina, M. Prieto, Jesús A. Santos, A. Álvarez‐Ordoñez   +5 more
semanticscholar   +1 more source

Comparative analysis of somatic variant calling on matched FF and FFPE WGS samples

BMC Medical Genomics, 2020
Research grade Fresh Frozen (FF) DNA material is not yet routinely collected in clinical practice. Many hospitals, however, collect and store Formalin Fixed Paraffin Embedded (FFPE) tumor samples.
Louise de Schaetzen van Brienen, M. Larmuseau, K. Van der Eecken, F. De Ryck, P. Robbe, A. Schuh, J. Fostier, P. Ost, K. Marchal   +8 more
semanticscholar   +1 more source

Whole Genome Sequencing for the Analysis of Drug Resistant Strains of Mycobacterium tuberculosis: A Systematic Review for Bedaquiline and Delamanid

Antibiotics, 2020
Tuberculosis (TB) remains the deadliest Infectious disease worldwide, partially due to the increasing dissemination of multidrug and extensively drug-resistant (MDR/XDR) strains.
Luisa Maria Nieto Ramirez, Karina Quintero Vargas, Gustavo Diaz   +2 more
doaj   +1 more source

Implementation of whole genome sequencing for tuberculosis diagnostics in a low-middle income, high MDR-TB burden country

Scientific Reports, 2021
Whole genome sequencing (WGS) is revolutionary for diagnostics of TB and its mutations associated with drug-resistances, but its uptake in low- and middle-income countries is hindered by concerns of implementation feasibility. Here, we provide a proof of
Monica Vogel, Christian Utpatel, Caroline Corbett, Thomas A. Kohl, Altyn Iskakova, Sevim Ahmedov, Uladzimir Antonenka, Viola Dreyer, Ainura Ibrahimova, Chynara Kamarli, Dilorom Kosimova, Vanessa Mohr, Evgeni Sahalchyk, Meerim Sydykova, Nagira Umetalieva, Abdylat Kadyrov, Gulmira Kalmambetova, Stefan Niemann, Harald Hoffmann   +18 more
doaj   +1 more source

Rapid, ultra low coverage copy number profiling of cell-free DNA as a precision oncology screening strategy. [PDF]

, 2017
Current cell-free DNA (cfDNA) next generation sequencing (NGS) precision oncology workflows are typically limited to targeted and/or disease-specific applications.
Alva, Ajjai S, Brockman, Scott, Chinnaiyan, Arul M, Chugh, Rashmi, Feng, Felix Y, Grasso, Catherine S, Gursky, Amy, Haakenson, Christine, Henderson, James, Herman, Kirk, Hovelson, Daniel H, Husain, Hatim, Hussain, Maha H, Kamberov, Emmanuel, Kandarpa, Malathi, Kang, Qing, Krauss, John C, Langmore, John, Liu, Chia-Jen, Lonigro, Robert J, Mills, Ryan E, Morgan, Todd M, Quist, Michael J, Ramnath, Nithya, Robinson, Dan, Smith, David C, Talpaz, Moshe, Tesmer, Tim, Tewari, Muneesh, Tomlins, Scott A, Tuck, Missy, Wang, Yugang   +31 more
core   +1 more source

s3-WGS v1 [PDF]

, 2020
s3WGS (symmetrical strand single-cell combinatorial indexing; whole genome sequencing) protocol for the capture of genomic reads in single-cells. See https://mulqueenr.github.io/scwgs/ for more information.
Andrew Adey, Ryan Mulqueen
openaire   +1 more source

NASP: an accurate, rapid method for the identification of SNPs in WGS datasets that supports flexible input and output formats.

Microbial Genomics, 2016
Whole-genome sequencing (WGS) of bacterial isolates has become standard practice in many laboratories. Applications for WGS analysis include phylogeography and molecular epidemiology, using single nucleotide polymorphisms (SNPs) as the unit of evolution.
J. Sahl, D. Lemmer, J. Travis, J. Schupp, J. Gillece, Maliha Aziz, E. Driebe, K. Drees, Nathan D Hicks, C. H. Williamson, Crystal M. Hepp, David Smith, Chandler C. Roe, D. Engelthaler, D. Wagner, P. Keim   +15 more
semanticscholar   +1 more source

The influence of an innovative antibacterial drug of the thiadiazinone class on the virulence factors of bacteria of the phylum Pseudomonadota, which chronically infect patients with cystic fibrosis

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Infections of the lower respiratory tract by bacteria of the Pseudomonadota phylum: Pseudomonas aeruginosa, Burkholderia spp., Achromobacter spp. are critical to the quality and life expectancy of patients with cystic fibrosis (CF).
Olga L. Voronina, Ekaterina A. Koroleva, Marina S. Kunda, Natalia N. Ryzhova, Ekaterina I. Aksenova, Lidia N. Kapotina, Stanislava A. Nelubina, Anna V. Lazareva, Nailya A. Zigangirova   +8 more
doaj   +1 more source

Preferences for the provision of whole genome sequencing services among young adults. [PDF]

PLoS ONE, 2017
OBJECTIVES:As whole genome sequencing (WGS) becomes increasingly available, clinicians will be faced with conveying complex information to individuals at different stages in life.
Christopher H Wade, Kailyn R Elliott
doaj   +1 more source