Results 51 to 60 of about 89,794 (315)

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

Advanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao, Ruixue Nie, Hailu Fan, Tenzin Ngodroup, Li Zhu, Hongbin Pan, Bo Zhang, Hao Zhang   +7 more
wiley   +1 more source

GT-WGS: an efficient and economic tool for large-scale WGS analyses based on the AWS cloud service

BMC Genomics, 2018
Background Whole-genome sequencing (WGS) plays an increasingly important role in clinical practice and public health. Due to the big data size, WGS data analysis is usually compute-intensive and IO-intensive.
Yiqi Wang, Gen Li, Mark Ma, Fazhong He, Zhuo Song, Wei Zhang, Chengkun Wu   +6 more
doaj   +1 more source

Study protocol: Whole genome sequencing Implementation in standard Diagnostics for Every cancer patient (WIDE)

BMC Medical Genomics, 2020
Background ‘Precision oncology’ can ensure the best suitable treatment at the right time by tailoring treatment towards individual patient and comprehensive tumour characteristics.
Kris G. Samsom, Linda J. W. Bosch, Luuk J. Schipper, Paul Roepman, Ewart de Bruijn, Louisa R. Hoes, Immy Riethorst, Lieke Schoenmaker, Lizet E. van der Kolk, Valesca P. Retèl, Geert W. J. Frederix, Tineke E. Buffart, Jacobus J. M. van der Hoeven, Emile E. Voest, Edwin Cuppen, Kim Monkhorst, Gerrit A. Meijer   +16 more
doaj   +1 more source

Whole Genome Sequencing Contributions and Challenges in Disease Reduction Focused on Malaria

Biology, 2022
Malaria elimination remains an important goal that requires the adoption of sophisticated science and management strategies in the era of the COVID-19 pandemic.
Olusegun Philip Akoniyon, Taiye Samson Adewumi, Leah Maharaj, Olukunle Olugbenle Oyegoke, Alexandra Roux, Matthew A. Adeleke, Rajendra Maharaj, Moses Okpeku   +7 more
doaj   +1 more source

IUPAP WG.9 [PDF]

Nuclear Physics News, 2017
The International Union of Pure and Applied Physics (IUPAP) established a working group for nuclear physics—Working Group 9 (WG.9)—during its general assembly meeting in 2005. The working group was an out-growth of an IUPAP Commission C12 committee that focused on nuclear physics facilities.
Tribble, Bob, Van Oers, Wim
openaire   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Compound heterozygosity as a cause of diagnostic difficulties in patients with hereditary diseases

Acta Biomedica Scientifica
Background. Up to 40 % of patients with suspected monogenic disorders remain undiagnosed when using targeted gene panels or exome sequencing, particularly in cases of compound heterozygosity where one pathogenic variant goes undetected.The aim.
M. E. Lobanov, O. I. Gumenyuk, Yu. V. Chernenkov, O. S. Groznova, Z. G. Afaunova, P. D. Polyakova, M. A. Sukhanova, R. A. Kapyov, D. N. Shemirzov, L. M. Shipilova   +9 more
doaj   +1 more source

Public attitudes in Japan toward participation in whole genome sequencing studies

Human Genomics, 2018
Background Recent innovations in gene analysis technology have allowed for rapid and inexpensive sequencing of entire genomes. Thus, both conducting a study using whole genome sequencing (WGS) in a large population and the clinical application of ...
Taketoshi Okita, Noriko Ohashi, Daijiro Kabata, Ayumi Shintani, Kazuto Kato   +4 more
doaj   +1 more source

Evaluating the clinical impact of routine whole genome sequencing in tuberculosis treatment decisions and the issue of isoniazid mono-resistance

BMC Infectious Diseases, 2022
Background The UK has implemented routine use of whole genome sequencing (WGS) in TB diagnostics. The WHO recommends addition of a fluoroquinolone for isoniazid mono-resistance, so early detection may be of use.
Mirae Park, Ajit Lalvani, Giovanni Satta, Onn Min Kon   +3 more
doaj   +1 more source