Results 81 to 90 of about 162,110 (330)

Molecular characterization of the A52 murine hepatocellular carcinoma cell line

Animal Models and Experimental Medicine, EarlyView.
Hepatocellular carcinoma (HCC) is a poor outcome cancer with limited therapeutic choices. To advance therapeutic development we genetically characterized the A52 murine HCC cell line. We noted genetic changes that match a subset of human HCC and this offers the opportunity to test novel targeted therapies in syngeneic mice.
Rhys Gillman, Eun Jin Sun, Miriam Wankell, Matt A. Field, Ulf Schmitz, Lionel Hebbard   +5 more
wiley   +1 more source

Profiling the gut microbiota to assess infection risk in Klebsiella pneumoniae-colonized patients

Gut Microbes
Vornhagen et al. introduced a model combining gut microbiota structure and Klebsiella pneumoniae genotype to assess infection risk in K. pneumoniae-colonized patients.
Flavio De Maio, Delia Mercedes Bianco, Giulia Santarelli, Roberto Rosato, Francesca Romana Monzo, Barbara Fiori, Maurizio Sanguinetti, Brunella Posteraro   +7 more
doaj   +1 more source

Extremely low-coverage whole genome sequencing in South Asians captures population genomics information

BMC Genomics, 2017
Background The cost of Whole Genome Sequencing (WGS) has decreased tremendously in recent years due to advances in next-generation sequencing technologies.
Navin Rustagi, Anbo Zhou, W. Scott Watkins, Erika Gedvilaite, Shuoguo Wang, Naveen Ramesh, Donna Muzny, Richard A. Gibbs, Lynn B. Jorde, Fuli Yu, Jinchuan Xing   +10 more
doaj   +1 more source

Fibroblast Transcriptomics in Molecular Diagnostics of a Comprehensive Dystonia Cohort

Annals of Neurology, EarlyView.
Objective Genomic sequencing leaves >50% of dystonia‐affected individuals without a diagnosis. Where DNA‐oriented approaches remain insufficient, integrating multiomics is essential to advance genome interpretation. Herein, we incorporated RNA sequencing (RNA‐seq) data from 167 patients with dystonia across a range of ages and presentations. Methods We
Alice Saparov, Ivana Dzinovic, Theresa Brunet, Vicente A. Yépez, Florian Hölzlwimmer, Elisabetta Indelicato, Birgit Assmann, Susann Badmann, Diana Ballhausen, Steffen Berweck, Felix Brechtmann, Melanie Brugger, Kevork Derderian, Felix Distelmaier, Philip Harrer, Denisa Harvanova, Petra Havrankova, Ann‐Kathrin Jaroszynski, Miriam Kolnikova, Robert Kopajtich, Anne Koy, Magdalena Krygier, Lukas Kunc, Katarina Kusikova, Oliver Maier, Maria Mazurkiewicz‐Bełdzińska, Christian Mertes, Ava Oberlack, Timo Roser, Alexandra Sitzberger, Ugo Sorrentino, Antonia M. Stehr, Katharina Vill, Matias Wagner, Holger Prokisch, Sylvia Boesch, Jan Necpal, Robert Jech, Juliane Winkelmann, Elisabeth Graf, Julien Gagneur, Matej Skorvanek, Michael Zech   +42 more
wiley   +1 more source

Identifying indels from WGS short reads of haploid genomes distinguishes variant-calling algorithms [PDF]

, 2022
Yee Mey Seah, M. Kathryn Stewart, Daniel R. Hoogestraat, Molly Ryder, Brad T. Cookson, Stephen J. Salipante, Noah G. Hoffman   +6 more
openalex   +1 more source

Sex‐Specific Genetic Architecture of ALS: Evidence of a Female Protective Effect?

Annals of Neurology, EarlyView.
Background Amyotrophic lateral sclerosis (ALS) shows sex differences in incidence and age of onset, yet the underlying biological mechanisms remain poorly understood. Methods We investigated sex‐specific genetic architecture in an Italian ALS cohort with whole‐genome sequencing (1,333 ALS cases, 755 controls).
Maurizio Grassano, Francesca Palumbo, Gabriele Mora, Salvatore Gallone, Giovanni De Marco, Ilaria Merulla, Claudia Paolantonio, Alessandra Maccabeo, Antonio Canosa, Umberto Manera, Rosario Vasta, Barbara Iazzolino, Marcella Testa, Giuseppe Fuda, Paolina Salamone, Giulia Marchese, Federico Casale, Cristina Moglia, Andrea Calvo, Giuseppe Borghero, Adriano Chiò   +20 more
wiley   +1 more source

Interconversion of Optical to Terahertz Pulses in Nonlinear Beta Barium Borate Crystal

Advanced Physics Research, EarlyView.
ABSTRACT Low‐temperature β‐phase barium borate (β‐BBO) is an important nonlinear crystal, widely utilized for optical second‐harmonic (SH) generation. Recent re‐measurements of refractive indices in the terahertz (THz) range reveal that β‐BBO is a positive uniaxial crystal.
Yingyu Guo, Boyuan Chen, Zhangshun Li, Zhiqiang Lan, Huiping Zhang, Lin Xi, Zuanming Jin, Yan Peng, Yiming Zhu   +8 more
wiley   +1 more source

WGS analysis of Listeria monocytogenes from rural, urban, and farm environments in Norway: Genetic diversity, persistence, and relation to clinical and food isolates [PDF]

, 2021
Annette Fagerlund, Lene Idland, Even Heir, Trond Møretrø, Marina Aspholm, Toril Lindbäck, Solveig Langsrud   +6 more
openalex   +1 more source

WEHRMACHTGEFÄNGNIS (WG) GERMERSHEIM

, 2022
On September 9, 1936, the German Army High Command (Oberkommando des Heeres, OKH) issued an order for the former detention facility of the Germersheim fortress, built between 1834 and 1861, to be expanded to serve as a military prison for the Wehrmacht (map 4d).
openaire   +1 more source

Archaeological Damage Assessment in Conflict Zones: Integrating Satellite Imagery and Ground Surveys in Daraa, Syria

Archaeological Prospection, EarlyView.
ABSTRACT Satellite remote sensing is among the most significant modern methodologies supporting field archaeology. In addition to its efficiency in identifying archaeological sites, remote sensing offers a safe and cost‐effective approach in conflict zones.
Amal Al Kassem, Kristen Hopper, Ismael M. Ibraheem, Andreas Maier, Mohammad Khair Nassrallah, Jürgen Richter   +5 more
wiley   +1 more source