A drug repurposing screen for whipworms informed by comparative genomics. [PDF]
PLoS Neglected Tropical Diseases, 2023 Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura. Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy.
Avril Coghlan +14 more
doaj +9 more sources
Defining the early stages of intestinal colonisation by whipworms [PDF]
Nature Communications, 2022 Whipworms are large parasites causing chronic disease in humans and other mammals. Here, the authors show how larvae create tunnels inside the gut lining and reveal the early host response to infection via Isg15 in mice and murine caecaloids.
David J. Thornton +2 more
exaly +14 more sources
PLoS Neglected Tropical Diseases, 2014 BackgroundWhipworms (Trichuris sp.) are a globally distributed genus of parasitic helminths that infect a diversity of mammalian hosts. Molecular methods have successfully resolved porcine whipworm, Trichuris suis, from primate whipworm, T.
Ria R Ghai, Colin A. Chapman
exaly +4 more sources
The narrow-spectrum anthelmintic oxantel is a potent agonist of a novel acetylcholine receptor subtype in whipworms [PDF]
PLoS Pathogens, 2021 In the absence of efficient alternative strategies, the control of parasitic nematodes, impacting human and animal health, mainly relies on the use of broad-spectrum anthelmintic compounds.
Susanna Cirera +2 more
exaly +4 more sources
Intestinal parasites infecting captive non-human primates in Italy [PDF]
Frontiers in Veterinary Science, 2023 Non-human primates (NHPs) living in captive conditions are susceptible to intestinal parasites that can contribute to mortality and morbidity, and cause zoonotic infections.
Silvia Rondón +6 more
doaj +2 more sources
Clinical and Diagnostic Findings in Dogs Infected with Trichuris vulpis: A Retrospective Study [PDF]
Veterinary SciencesTrichuris vulpis is a parasite of the large intestine of canids and has a global distribution. Despite its well-established epidemiology, the question of its pathogenicity in dogs remains debated.
Mario Cervone +5 more
doaj +2 more sources
An Unpleasant Souvenir: Whipworm as an Incidental Finding During a Screening Colonoscopy [PDF]
Journal of Investigative Medicine High Impact Case ReportsTrichuriasis is a neglected tropical disease caused by Trichuris trichiura that spreads through the ingestion of embryonated eggs in contaminated soil, water, or food.
Lefika Bathobakae MD, MPH +8 more
doaj +2 more sources
Effectiveness of Deworming Strategy in Reducing Anemia in Children: An Overview of Reviews [PDF]
Indian Journal of Community MedicineBackground: The most common infections transmitted through soil in humans are caused by roundworms, whipworms, and hookworms. The overview of reviews aimed to determine the effectiveness of deworming interventions on anemia in children.
Anil Chauhan +4 more
doaj +2 more sources
Soil-transmitted helminths associated with BMI in schoolchildren of Chakdara, Lower Dir, Pakistan [PDF]
Journal of Advanced Veterinary and Animal ResearchObjective: This study aimed to determine the association between soil-transmitted helminths and body mass index (BMI) among the school children of Chakdara, Lower Dir, Pakistan. Materials and Methods: Students aged 5–15 years participated in this study.
Wali Khan +8 more
doaj +2 more sources
Retrospective Survey of Dog and Cat Endoparasites in Ireland: Antigen Detection [PDF]
Animals, 2022 Endoparasites of dogs and cats, play an important role in both veterinary medicine and public health. Untreated and stray dogs and cats, in particular, play an important role in contaminating the environment with important zoonotic parasites.
Theo de Waal +5 more
doaj +2 more sources