Hatching of whipworm eggs induced by bacterial contact is serine-protease dependent. [PDF]
PLoS PathogensWhipworms (Trichuris spp) are ubiquitous parasites of humans and domestic and wild mammals that cause chronic disease, considerably impacting human and animal health.
David Goulding +8 more
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Whipworm infection remodels the gut microbiome ecosystem and compromises intestinal homeostasis in elderly patients revealed by multi-omics analyses [PDF]
Frontiers in Cellular and Infection MicrobiologyIntroductionWhipworm (Trichuris trichiura) coexists with symbiotic microbiota in the gastrointestinal ecosystem. There is a paucity of data on the association between whipworm infection and the gut microbiota composition in elderly individuals.
Benguang Zhang +15 more
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Transcriptional responses of mouse proximal colon and colonoids during early whipworm infection [PDF]
mBioTrichuriasis, caused by the parasitic nematode Trichuris trichiura, affects 429–508 million people worldwide. Although the early phase of whipworm infection is crucial for establishing infection, its underlying molecular mechanisms remain unclear.
Hyeim Jung +3 more
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Whipworm secretions and their roles in host-parasite interactions [PDF]
Parasites & Vectors, 2022 Whipworm (Trichuris) is a genus of roundworms that causes gastrointestinal infections in humans and animals. Of particular interest are T. trichiura, the causative agent of human trichuriasis, a neglected tropical disease that affects 477 million people ...
Rebecca K. Shears, Richard K. Grencis
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A genome-scale metabolic model of parasitic whipworm
Nature Communications, 2023 Genome-scale metabolic models are widely used to enhance our understanding of metabolic features of organisms, host-pathogen interactions and to identify therapeutics for diseases.
Ömer F. Bay +4 more
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Whipworm-Associated Intestinal Microbiome Members Consistent Across Both Human and Mouse Hosts
Frontiers in Cellular and Infection Microbiology, 2021 The human whipworm Trichuris trichiura infects 289 million people worldwide, resulting in substantial morbidity. Whipworm infections are difficult to treat due to low cure rates and high reinfection rates.
Bruce A Rosa +2 more
exaly +4 more sources
2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm. [PDF]
PLoS Neglected Tropical Diseases, 2018 The human whipworm Trichuris trichiura is a parasite that infects around 500 million people globally, with consequences including damage to physical growth and educational performance.
Frederick A Partridge +12 more
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Does Whipworm Increase the Pathogenicity ofCampylobacter jejuni?A Clinical Correlate of an Experimental Observation [PDF]
Canadian Journal of Gastroenterology & Hepatology, 2004 Campylobacter jejuni is a leading cause of acute diarrhea worldwide, usually mild and self-limiting. No adequate hypothesis has yet been formulated to explain why in an otherwise healthy host this infection is occasionally severe.
Geoffrey W Gardiner, Gabor Kandel
exaly +3 more sources
Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection. [PDF]
PLoS Pathogens, 2019 The whipworm Trichuris trichiura is a soil-transmitted helminth that dwells in the epithelium of the caecum and proximal colon of their hosts causing the human disease, trichuriasis. Trichuriasis is characterized by colitis attributed to the inflammatory
María A Duque-Correa +16 more
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Infection with male and female Trichuris trichiura diagnosed in a non‐endemic area [PDF]
Clinical Case Reports, 2023 Key Clinical Message Trichuris trichiura parasitizes only humans through fecal‐oral transmission. In non‐endemic areas, the frequency of endoscopic identification has been increasing due to the increasing number of immigrants from endemic countries.
Masaki Inoue +5 more
doaj +2 more sources