Whipworm and roundworm infections [PDF]
Nature Reviews Disease Primers, 2020 Trichuriasis and ascariasis are neglected tropical diseases caused by the gastrointestinal dwelling nematodes Trichuris trichiura (a whipworm) and Ascaris lumbricoides (a roundworm), respectively. Both parasites are staggeringly prevalent, particularly in tropical and subtropical areas, and are associated with substantial morbidity.
Else, Kathryn J. +9 more
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Whipworm secretions and their roles in host-parasite interactions [PDF]
Parasites & Vectors, 2022 Whipworm (Trichuris) is a genus of roundworms that causes gastrointestinal infections in humans and animals. Of particular interest are T. trichiura, the causative agent of human trichuriasis, a neglected tropical disease that affects 477 million people ...
Rebecca K. Shears, Richard K. Grencis
doaj +3 more sources
2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm. [PDF]
PLoS Neglected Tropical Diseases, 2018 The human whipworm Trichuris trichiura is a parasite that infects around 500 million people globally, with consequences including damage to physical growth and educational performance.
Frederick A Partridge +12 more
doaj +6 more sources
A genome-scale metabolic model of parasitic whipworm
Nature Communications, 2023 Genome-scale metabolic models are widely used to enhance our understanding of metabolic features of organisms, host-pathogen interactions and to identify therapeutics for diseases.
Ömer F. Bay +4 more
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Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection. [PDF]
PLoS Pathogens, 2019 The whipworm Trichuris trichiura is a soil-transmitted helminth that dwells in the epithelium of the caecum and proximal colon of their hosts causing the human disease, trichuriasis. Trichuriasis is characterized by colitis attributed to the inflammatory
María A Duque-Correa +16 more
doaj +6 more sources
Bacteria-induced egg hatching differs for Trichuris muris and Trichuris suis [PDF]
Parasites & Vectors, 2015 Background Eggs of the porcine whipworm Trichuris suis are currently explored in human clinical trials as a treatment of immune-mediated diseases. In this context, only the infective, embryonated eggs, constitute the Active Pharmaceutical Ingredient (API)
Nermina Vejzagić +5 more
doaj +2 more sources
Trichuris muris whey acidic protein induces type 2 protective immunity against whipworm. [PDF]
PLoS Pathogens, 2018 Human whipworm (Trichuris trichiura) infects approximately 1 in 15 people worldwide, representing the leading infectious cause of colitis and subsequent, inflammatory bowel disease (IBD).
Neima Briggs +14 more
doaj +2 more sources
Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo. [PDF]
PLoS Neglected Tropical Diseases, 2017 Trichuris trichiura is a human parasitic whipworm infecting around 500 million people globally, damaging the physical growth and educational performance of those infected.
Frederick A Partridge +11 more
doaj +2 more sources
New evidence for the antiquity of the intestinal parasite Trichuris (whipworm) in Europe
, 2004 The whipworm, Trichuris trichiura L., is one of the most common human intestinal parasites worldwide, yet little is known of its origin and global spread.
Dark, P.
core +9 more sources
Caecal Epithelium-Derived Thymic Stromal Lymphopoietin is not Required for Protective Immunity Against Whipworm. [PDF]
Eur J ImmunolImmunity to Trichuris muris infection is unimpacted by epithelial knockout of TSLP expression. Imaging of transcription in the caecum reveals Tslp transcription throughout infection in EpCAM‐, Foxl1‐, Ccl24‐ lamina propria‐resident cells, contributing during the expulsion phase of infection. ABSTRACT Recent research examining classical type two alarmin
Lynch CP +5 more
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